ID A0A1I4K4D8_9BACI Unreviewed; 481 AA.
AC A0A1I4K4D8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=NAD(+) hydrolase ThsA {ECO:0000256|ARBA:ARBA00035033};
DE EC=3.2.2.5 {ECO:0000256|ARBA:ARBA00034327};
GN ORFNames=SAMN04487943_103350 {ECO:0000313|EMBL:SFL73660.1};
OS Gracilibacillus orientalis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Gracilibacillus.
OX NCBI_TaxID=334253 {ECO:0000313|EMBL:SFL73660.1, ECO:0000313|Proteomes:UP000198565};
RN [1] {ECO:0000313|EMBL:SFL73660.1, ECO:0000313|Proteomes:UP000198565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.4250 {ECO:0000313|EMBL:SFL73660.1,
RC ECO:0000313|Proteomes:UP000198565};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.5;
CC Evidence={ECO:0000256|ARBA:ARBA00034990};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00034990};
CC -!- SIMILARITY: Belongs to the soluble Thoeris ThsA family.
CC {ECO:0000256|ARBA:ARBA00035014}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00236}.
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DR EMBL; FOTR01000003; SFL73660.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4K4D8; -.
DR STRING; 334253.SAMN04487943_103350; -.
DR OrthoDB; 1688888at2; -.
DR Proteomes; UP000198565; Unassembled WGS sequence.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd01406; SIR2-like; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR039444; SIR2-like.
DR InterPro; IPR026590; Ssirtuin_cat_dom.
DR InterPro; IPR041486; ThsA_STALD.
DR Pfam; PF13289; SIR2_2; 1.
DR Pfam; PF18185; STALD; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR PROSITE; PS50305; SIRTUIN; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 1..283
FT /note="Deacetylase sirtuin-type"
FT /evidence="ECO:0000259|PROSITE:PS50305"
SQ SEQUENCE 481 AA; 54304 MW; A0B2D00E1CBC07AE CRC64;
MEYNPSIQEF LRTYVKAIQD SNAAIFAGAG LSRPAGYVDW KELLREVAQD LQLDIDQESD
LIALAQYHVN EFSGRGKINQ ILIEEFTRSV STSHNHKILS HLPISTYWTT NYDQLIETNL
EAVGKKVDKK ITSETMTYSV PGSDVTVYKM HGDSTLPHDA VLTKDDYEGY DQKRQIYSTA
LRGDLVSKTF LFIGFSFDDP NLSQILSRIR ILLNENKRTH YCFMKKVKAN DFNGNDDEFR
YAEIKQNLKI KDLMRYGIKV LLIDDYPEIT EILQHIASLI IRKNIFVSGS ASDYGDWGEE
KSFEFSTSLS KALIKNNNNI VSGFGLGIGS CIISGALEEL YSSQNNKVEQ RLKCRPFPQN
TTGGLSIKDL WTKYRNDMIS NIGISVFIFG NKIDTETKDV IDANGMVEEF DISIEKGAIP
IPVGATGFTS KILWQRVMDD FGPLVGIEDL KPLYSDLGDE SKNSEELIET VVKIINLLAK
H
//
