ID   A0A1I4N901_9RHOB        Unreviewed;      1250 AA.
AC   A0A1I4N901;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Multidrug efflux pump {ECO:0000313|EMBL:SFM11777.1};
GN   ORFNames=SAMN04488042_10443 {ECO:0000313|EMBL:SFM11777.1};
OS   Shimia aestuarii.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae.
OX   NCBI_TaxID=254406 {ECO:0000313|EMBL:SFM11777.1, ECO:0000313|Proteomes:UP000199144};
RN   [1] {ECO:0000313|EMBL:SFM11777.1, ECO:0000313|Proteomes:UP000199144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15283 {ECO:0000313|EMBL:SFM11777.1,
RC   ECO:0000313|Proteomes:UP000199144};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOTQ01000004; SFM11777.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I4N901; -.
DR   STRING; 254406.SAMN04488042_10443; -.
DR   OrthoDB; 9798415at2; -.
DR   Proteomes; UP000199144; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 4.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF33; RND SUPERFAMILY EFFLUX PUMP PERMEASE COMPONENT; 1.
DR   Pfam; PF00873; ACR_tran; 3.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199144};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        336..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        387..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        432..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        464..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        510..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        549..571
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        592..621
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1000..1021
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1028..1048
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1054..1076
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1103..1123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1143..1171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1213..1250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1220..1234
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1250 AA;  136401 MW;  D95D28F60AE1BAF6 CRC64;
     MIGIVDWAAS RARMVMAFIL LSLAVGGYAY WGLPKEGEPD IQIPGLFVSV PFPGISANDS
     ETMLVKPMET ELSDIDGLKK MSATAAEGYA GIFLEFEFGW DKSRVMADVR EAMNTAEGKF
     PDGFEKYSIN EINFSEFPII IVNLTGDVPE RTMFRIAKSL QDKLESLDAV LEAGIAGNRD
     EMVEVVIDPL RLESYNVTAT ELINVVVNNN QLIAAGEVDS AQGSFAVKIP SSFDKPRDIY
     DLPVKTNGDR VVTLGDLAEI NLTFEDRAGT ARFNGENTVA LQVVKRKGFN LIDTAQLVKE
     VVAAEEADWP DELRAAVEVG TSNDQSRVVG SMVSQLEGSV LTAIALVMIV VLAALGTRAA
     LLVGFAIPTS FLLCFALLAM MEVTISNIVM FGLILAVGML VDGAIVVVEY ADKRINEGIG
     PMHAYVEAAK RMFWPIVSST ATTLCAFLPM LFWPGVPGEF MGMLPVTLIF VLSASLVVAL
     IYLPVMGGVS GRLSRLFHRA SEGLRARTPY WLRALLVPPS LYLIFVGAMQ TLNPAYLLGD
     GAPQGGLMAF LPGFILFMAG AFAASITLDA ARIERKRKTV KAGFRLTPFG WFIKLIAGNP
     IMPLVSIGAV IAVVIAVFGY FGENNKGVEF FVESEPEQAI VYVKARGNLS LEQKDRLVSQ
     AEAVVLAHPG VKTAFAFAGE GGLDSNTGGA QAPKDMIGQI QLETIPWEDR PDVHEPWFTI
     PILNYTVTRA IKDERWDGNT VLDELTVELD KIAGVQIEIL EASRGPASAK PVHLRVKGDN
     WEDLLAAATI AREKMDATPG LTLIEDTRPL PGIDWEINVD VAKAGRYGAD VRTVGAMVQL
     VTRGILLDTM RVDSSDEEIE IRVRLPESDR VLSTLDTLKV RTTEGLVPLS NFITREPVEK
     LAEINRVDQT RYFDVKAGIE SGMMVLHNAE TGEREVLSAE SWNNDTALQE DWRAKGFKAT
     VLTPNERIAT LTEWLETDPF PRGIDFEWTG DQEDEAESQA FLQTAFAGAL GLMFIILLAQ
     FNSVYNSVLV LLAVVLSTTG VLIGMLVMDQ AFSIIMTGTG IVALAGIVVN NNIVLIDTYQ
     EYSQYMPRIE AIVRTAQSRI RPVLLTTITT MAGLAPMMFG LSLDFINGGY SIDSPTSLWW
     KQLATAVVFG LGIATVLTLV FTPSMLALRV WASTYFRWLM MLLARLSFGR TSKAGQDWAL
     RRAARKLRGP VIIWDDTPAP EKTPEAEDSA EGENESPRTP NAPDALRAAE
//