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Database: UniProt
Entry: A0A1I4NCZ3_9BACL
LinkDB: A0A1I4NCZ3_9BACL
Original site: A0A1I4NCZ3_9BACL 
ID   A0A1I4NCZ3_9BACL        Unreviewed;       297 AA.
AC   A0A1I4NCZ3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 6.
DE   RecName: Full=Formyltetrahydrofolate deformylase {ECO:0000256|HAMAP-Rule:MF_01927};
DE            EC=3.5.1.10 {ECO:0000256|HAMAP-Rule:MF_01927};
DE   AltName: Full=Formyl-FH(4) hydrolase {ECO:0000256|HAMAP-Rule:MF_01927};
GN   Name=purU {ECO:0000256|HAMAP-Rule:MF_01927};
GN   ORFNames=SAMN03159341_117111 {ECO:0000313|EMBL:SFM13442.1};
OS   Paenibacillus sp. 1_12.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae;
OC   Paenibacillus.
OX   NCBI_TaxID=1566278 {ECO:0000313|EMBL:SFM13442.1, ECO:0000313|Proteomes:UP000198699};
RN   [1] {ECO:0000313|EMBL:SFM13442.1, ECO:0000313|Proteomes:UP000198699}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1_12 {ECO:0000313|EMBL:SFM13442.1,
RC   ECO:0000313|Proteomes:UP000198699};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of 10-formyltetrahydrofolate
CC       (formyl-FH4) to formate and tetrahydrofolate (FH4).
CC       {ECO:0000256|HAMAP-Rule:MF_01927}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-
CC         tetrahydrofolate + formate + H(+); Xref=Rhea:RHEA:19833,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:57454; EC=3.5.1.10;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01927};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.
CC       {ECO:0000256|HAMAP-Rule:MF_01927}.
CC   -!- SIMILARITY: Belongs to the PurU family. {ECO:0000256|HAMAP-
CC       Rule:MF_01927}.
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DR   EMBL; FOTE01000017; SFM13442.1; -; Genomic_DNA.
DR   UniPathway; UPA00074; UER00170.
DR   Proteomes; UP000198699; Unassembled WGS sequence.
DR   GO; GO:0008864; F:formyltetrahydrofolate deformylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd08648; FMT_core_Formyl-FH4-Hydrolase_; 1.
DR   HAMAP; MF_01927; PurU; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR041729; Formyl-FH4-Hydrolase_C.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR036477; Formyl_transf_N_sf.
DR   InterPro; IPR004810; PurU.
DR   PANTHER; PTHR42706; PTHR42706; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   PRINTS; PR01575; FFH4HYDRLASE.
DR   SUPFAM; SSF53328; SSF53328; 1.
DR   TIGRFAMs; TIGR00655; PurU; 1.
DR   PROSITE; PS51671; ACT; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000198699};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01927};
KW   One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_01927};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198699}.
FT   DOMAIN       19    100       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   COILED       68     88       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE    241    241       {ECO:0000256|HAMAP-Rule:MF_01927}.
SQ   SEQUENCE   297 AA;  33867 MW;  9EB47E4298728BA3 CRC64;
     MTPNIAPKGN RDDLKNRARM LVACPDQPGI VAAVSQFLYE HGANIVQSDQ YTIDPQGGMF
     YIRIEFDLDN LDGRQEQLRN EFAKVAERFS MDWTINRAGR KKRLAIFVSK EDHALLELLW
     QWQAGDLEAD IAMVISNHND LRGLVESFGI AYYHIPVTAE TKAEAERRQL ELVMDQVDAV
     VLARYMQIIS PKFIEHFTNR IINIHHSFLP AFVGGKPYAQ AHNRGVKIIG ATAHYVTEEL
     DGGPIIEQDV QRVSHRDNVD DLKRIGRHIE RIVLARAVSW HVEDRVIVHG NKTVVFN
//
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