ID A0A1I4PRQ5_ECTMO Unreviewed; 865 AA.
AC A0A1I4PRQ5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN05421721_102151 {ECO:0000313|EMBL:SFM30065.1};
OS Ectothiorhodospira mobilis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Ectothiorhodospira.
OX NCBI_TaxID=195064 {ECO:0000313|EMBL:SFM30065.1, ECO:0000313|Proteomes:UP000199556};
RN [1] {ECO:0000313|EMBL:SFM30065.1, ECO:0000313|Proteomes:UP000199556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4180 {ECO:0000313|EMBL:SFM30065.1,
RC ECO:0000313|Proteomes:UP000199556};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FOUO01000002; SFM30065.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4PRQ5; -.
DR STRING; 195064.SAMN05421721_102151; -.
DR Proteomes; UP000199556; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000199556}.
FT DOMAIN 688..704
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 614..621
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 865 AA; 94906 MW; 1CD0DC71921A4C54 CRC64;
MTDPQDLSAH TPMMRQYLAI KAEYPDTLLF YRMGDFYELF YEDAHRAAAL LDITLTKRGQ
SAGAPIPMAG VPVHAVESYL ARLLRQGESV AICEQVSDPA TAKGPVERKV VRVVTPGTVT
EEALLDERQD NLLVALCPAK ERTGLAVLDL SGGRFQVQEL EGEEALQGEL ERLQPAEILL
PEGADLPGGE RPGVRHYAPW HFEVGAARER LTRQFGTRDL AGFGCESMDR AVAAAGALLH
YVQETQMSAL PHIDGLSVQE RGAGIILDAA TRRNLEITTN LSGGRENTLA AVLDRTVTAM
GSRLLRRWLH QPLRDRDALR ARHQAVGELR DRGTLEPLRE LLEGIGDLER ILARVALGSA
RPRDLATLRD SLAQLPALQS TLADLEAPRL RALADQVGRH PGVVDLLNRA ILPQPPVLIR
DGGVMAAGYD PELDELRALS ENADQFLLDL EQRERERTGI PNLKVAYNRV HGYYIEISRA
QAGRAPEDYT RRQTLKGAER FITPELKRFE DQVLSARERA LAREKRLYEE LLQTLLEPLA
ALRRSAEGLA ELDVLANLAE RAQALGYTAP ELDDTPGLDI RGGRHPVVEQ VLDDPFVPND
LVMDEGRRML VITGPNMGGK STYMRQAALI VLMAHAGGFV PAEHARLGPV DRIFTRIGAA
DDLASGRSTF MVEMTEAAAI LHHASAHSLV LMDEIGRGTS TFDGLSLAWA CAEHLARHNR
AFTLFATHYF ELTALPDTLP GIANVHIDAV EHGERIIFLH TLKEGPANQS YGLHVAALAG
VPAGVIRRAR ERLAELERQN LGDAGDTAQL SLFPPQAPPA TPDPACEALR EAVQGLDPDE
MTPRQALEAL YRLRRLLDAP DTDTP
//
