ID A0A1I4R3L3_9EURY Unreviewed; 677 AA.
AC A0A1I4R3L3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=SAMN04488696_1343 {ECO:0000313|EMBL:SFM46849.1};
OS Methanolobus profundi.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanolobus.
OX NCBI_TaxID=487685 {ECO:0000313|EMBL:SFM46849.1, ECO:0000313|Proteomes:UP000198535};
RN [1] {ECO:0000313|EMBL:SFM46849.1, ECO:0000313|Proteomes:UP000198535}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mob M {ECO:0000313|EMBL:SFM46849.1,
RC ECO:0000313|Proteomes:UP000198535};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; FOUJ01000002; SFM46849.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4R3L3; -.
DR STRING; 487685.SAMN04488696_1343; -.
DR OrthoDB; 146201at2157; -.
DR Proteomes; UP000198535; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}.
FT DOMAIN 218..336
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 493..633
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 355..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 74460 MW; 3E1EE7762D5AA3A1 CRC64;
MTDKACDMNS SRIRLLDEST INKIAAGEVI ERPASVVKEL IENSIDAHAT DVRVEIGGYG
TKSMLIVDNG IGMSHTDASI AFKKHATSKI NRIEDLDSIL TMGFRGEALA SIASVAKVEL
VTRQESELEG TKVVVDSSGI RSITSAGTAV GTSILVNDLF YSTPARKKYL KSARTEIAHI
VDVVSRNCLA HPDVSFTLII DGKVTLRSPS SVKMLDSIVH LYGADVARSL VPLEYDSDLI
SISGYISKPE LTRSGKDLQV FLINGRPIFS KQLSNAVRLG YYTLLPKGRY PAAFLNFTIN
PVNVDVNVHP AKREVRLSHE KEISVMIVSA VEKALARDSL VPEVQLNKKD VPVQSRLNVR
EPERPSSSSS SEISNAYKAT GSVRLPASTE VPEQDGSGSA VSSRSQVPVP STASSDGYQA
VSNSETTAPI IIPDSSSDEI SRKNVIKEEK EPYQYPAKDT QRRLKKSERL QMSVTLDEVA
ELNASFTPSD VKVYGQYADL YIISDMDGKL ILIDQHAAHE RIMYEQVLRM QDLGWQELIT
PVTLDLSQKE KAIIEEFIPQ LEEMGFSVSE FGPKSYVVTT VPSIFGKLEN TDVIHDIISD
LLSVGRVKED TERYDLLCST MACRAAIKAG AVCNTKQMEE LIRQLMLCNN PYTCPHGRPT
MISFTMDELA KLFKRTG
//
