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Database: UniProt
Entry: A0A1I4RFN3_9DELT
LinkDB: A0A1I4RFN3_9DELT
Original site: A0A1I4RFN3_9DELT 
ID   A0A1I4RFN3_9DELT        Unreviewed;       681 AA.
AC   A0A1I4RFN3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 9.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SFM51082.1};
GN   ORFNames=SAMN05660836_00595 {ECO:0000313|EMBL:SFM51082.1};
OS   Thermodesulforhabdus norvegica.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Syntrophobacterales;
OC   Syntrophobacteraceae; Thermodesulforhabdus.
OX   NCBI_TaxID=39841 {ECO:0000313|EMBL:SFM51082.1, ECO:0000313|Proteomes:UP000199611};
RN   [1] {ECO:0000313|EMBL:SFM51082.1, ECO:0000313|Proteomes:UP000199611}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 9990 {ECO:0000313|EMBL:SFM51082.1,
RC   ECO:0000313|Proteomes:UP000199611};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
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DR   EMBL; FOUU01000001; SFM51082.1; -; Genomic_DNA.
DR   BioCyc; GCF_900114975:BM091_RS02960-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000199611; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000199611};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199611}.
FT   DOMAIN      318    497       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      501    582       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   681 AA;  75432 MW;  E38FE76D4E4888B5 CRC64;
     MAEPITQFYV RFYNSPVGKI AIVTMDNGED YKKPNVFNEG ALESLNKAIN TVLVEKDVKG
     LLLTGKPYIF AAGADLTQVP FITTFEQGYA VAKAGHDTFK RIMDLPFPTV AAINGVALGG
     GLEIALYCDY RTVSRSAQAI GFPECFIGLV PGWGGCTLTT KLVGPEKAVE LIIYNALNQN
     RMIDGTKLYE MGLADRLFDG AEFLDESLLF LQDIISGKVK VERPETKMNA VKTVVKQARE
     FIDSKVHGAA PAPYRALEII EGVCSNDIEW GFEEENKALG DLIKSRQCKC SIYAFDLVNR
     YAKKVKGIPD AKPMKINKVG ILGAGLMASQ LAHLFIYRLG VPVVMKDIKQ EFVDKGCAYV
     ASEFQKMAQK GRITEARARY LTSLLKGTLD YGDFADCDFV IEAVFEEMSV KKQVFAEVEQ
     VVRPDCILAT NTSSLSVTEM GADLKHPERV VGFHFFNPVA VLPLIEVIKT PKTNDVTLAT
     AFDLAKKLKK TGILVKDSPA FLVNRLLTKM MVDCLSMVDQ GASFQQVDNA LLALGLPMAP
     FDLLALVGPA VAYHVNETLH YHLSPERFPL NQNLKRIVDA GKRSIYIQSG KTKKVDPEIE
     KMWVRVDNRE FLDEEIRDIC LENLAREIDL ILQEGVVQSS RDVDLAMIMG AGWPFFMGGI
     TMYLDMAGIT PRVLQKVFFS V
//
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