ID A0A1I4RX62_9PROT Unreviewed; 754 AA.
AC A0A1I4RX62;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Tyrosine-protein kinase Etk/Wzc {ECO:0000313|EMBL:SFM56809.1};
GN ORFNames=SAMN05421880_12132 {ECO:0000313|EMBL:SFM56809.1};
OS Nitrosomonas nitrosa.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosomonas.
OX NCBI_TaxID=52442 {ECO:0000313|EMBL:SFM56809.1, ECO:0000313|Proteomes:UP000199561};
RN [1] {ECO:0000313|EMBL:SFM56809.1, ECO:0000313|Proteomes:UP000199561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nm146 {ECO:0000313|EMBL:SFM56809.1,
RC ECO:0000313|Proteomes:UP000199561};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; FOUF01000021; SFM56809.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4RX62; -.
DR STRING; 52442.SAMN05421880_12132; -.
DR OrthoDB; 9808257at2; -.
DR Proteomes; UP000199561; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:SFM56809.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000199561};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 38..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..113
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 398..478
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 569..687
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 754 AA; 83996 MW; 94796EBDBAA6F02A CRC64;
MPNTPNDHAK AQLDYQFDQD DDEINLGEVL GILLDSKWLI IGITFVALSL GVAKTFLDRP
VYKADGLLQA KENTQSLAGL EPLTGLIDGK TPVLAEIELI KSRMILGKTI QSLHLDIVAK
PKYFPIIGEA IARQFEKRNP DNAVANPLFD QIHYAWGGEA IQVDTFAVPA DWEDEELILQ
AGKQGHFKLI RDDEIILEGE VGKLASMQLE GEKHSVSIFV SLLKARPDTY FTVMRQSKNQ
AIRNLRNSVS VTEKGKNTGI LELTVESHSP DAAVSIVNEI ANIYVQQNVD QKSAESQKTL
EFLEKQLPIV KDQLEAATVA LNEYRTRQGS IDLDLETQNI LKSAVELRTQ ITLLQQKRDE
LRQRYTESHP TIISIDKQIA RLQSQITAHD NKIEVLPETQ QVILRLSRDV KVNTELYTTL
LNNAQTLRIA KAGTIGNVRI IDYALLPDEP IKPKKLLIIG IAVILGIILG IVTAFVRRLL
NRGVEDPHLI EKQLNIPVYA TVPHSKSQKA LYGKLKKPAS SRHYTPVILA LENREDIAIE
SLRSLRTTLH FAFLEARNNI IMITGPSPNI GKTFISVNLA VVMADAGKKV LLIDGDMRRG
LIHKPLGLGR DNGLSELIFD AIKIEEAIHH IPQANIDFIP TGAIPPNPSE LLLHERFGHF
LENISAQYDL VIIDSPPILA VTDAAIIGRL ASATLMVVKA GEHPMRELEQ STRRLIQAGT
RLKGIVFNDL PQVSARHGYS YGKYVYQYSY KKGK
//
