ID A0A1I4SGS1_9ACTN Unreviewed; 1033 AA.
AC A0A1I4SGS1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Amino acid adenylation domain-containing protein/thioester reductase domain-containing protein {ECO:0000313|EMBL:SFM63493.1};
GN ORFNames=SAMN04487980_1003314 {ECO:0000313|EMBL:SFM63493.1};
OS Streptomyces sp. cf124.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761903 {ECO:0000313|EMBL:SFM63493.1, ECO:0000313|Proteomes:UP000198530};
RN [1] {ECO:0000313|EMBL:SFM63493.1, ECO:0000313|Proteomes:UP000198530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF124 {ECO:0000313|EMBL:SFM63493.1,
RC ECO:0000313|Proteomes:UP000198530};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOUV01000003; SFM63493.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4SGS1; -.
DR Proteomes; UP000198530; Unassembled WGS sequence.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd05235; SDR_e1; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR44845:SF6; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR PANTHER; PTHR44845; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450}.
FT DOMAIN 553..628
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 514..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1033 AA; 109670 MW; C3BD174BE1EE7734 CRC64;
MSETNWQVAG AEVDHGPYRP VATLIEEQAD RTPGRIALVH RGETETALTY AEFDALANGL
AAELASAGVR EGDLVPLMIG NSVELPLCMV ALMKLGAVFV PCDPAWPEER LRTVLQVLAP
PLALTSGSLV RTDGRSRVVS HRAIVPSTER PGRRPAPDSP VYGVFTSGTT GVPKCAVNLH
GGLTNRFRFM SRYFAATGDE VVLQNSRHTF DSAIWQLLWP LTTGGRTIVP EQGEFLDLER
TVDTIARYGV TVTDFVPAIL GMLVALLEAE PAHVARVASL RHLVVGGEEI IPHAVHRLRE
LVPGLGITNG YGPSEASIGM VFHRVDGTEG DHIPLGRPID NCYALVDAAD ADGIGEILIG
GACLGAGYVG EPELTAEAFV PNTSPGVPGE RLYRTGDLGR FDDAGLLRFV GRRDRQAQVD
GVRVELREIE TTAESCPGVI QAKALTLRRS GRTRLVVAAA AEGGTTPAAL RRHLASLLPR
VQVPRHCFVL QALPLTDNGK VDLRALRTIV EEKLGPGTGS GTGTGTATGA GIGDDAGITR
AEGIAGLTRG EHAGGLTRAE RLAEVMGAVL DRPGFGVRDD FLDHGGDSLT ALTAVLRIRE
TLGVRVGISD LHAHRTPAAL ATAVPGDGDA VMPAEDVAAL MERDAELPDD LAALARTAAG
ARPAPPPRTV LVTGATGFVG ARAVHRLLTA TGARVVCVVR ARDDAHARHR LREALTAQGL
WDESLAGRLD ARRGDLARDR FGWTRETWEA YAARCDAVLH IGALVNFLLD YRAHRPANVD
GTTEVLRFAL SGRTKALHHV STLGVLDREA SGARECARDR LGEDFDPARA ATPTSGYSRS
KWVAERLVLA ARRLGAPVTL YRLGEIMPAA DNGVPNPKAL THLLLSAFHR LGLRPDVPMR
SDYTPVDEAA ARLVAGLAEP AEGAVHHVFR DGGADFASLA LTEVERAVPV PEFMAALRAA
AAEDAGSAAA VLDAVLTLLP ASGPDGAPDF RRLLTDNPRL FTRASCTALD ARHGLRERPL
EAAVAAYRTT LTQ
//
