ID   A0A1I4TDW1_9PSEU        Unreviewed;      1338 AA.
AC   A0A1I4TDW1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=ATP-dependent helicase HrpA {ECO:0000313|EMBL:SFM74856.1};
GN   ORFNames=SAMN05421805_1011394 {ECO:0000313|EMBL:SFM74856.1};
OS   Saccharopolyspora antimicrobica.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharopolyspora.
OX   NCBI_TaxID=455193 {ECO:0000313|EMBL:SFM74856.1, ECO:0000313|Proteomes:UP000199398};
RN   [1] {ECO:0000313|EMBL:SFM74856.1, ECO:0000313|Proteomes:UP000199398}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CPCC 201259 {ECO:0000313|EMBL:SFM74856.1,
RC   ECO:0000313|Proteomes:UP000199398};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOUP01000001; SFM74856.1; -; Genomic_DNA.
DR   STRING; 455193.SAMN05421805_1011394; -.
DR   Proteomes; UP000199398; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   CDD; cd17989; DEXHc_HrpA; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR024590; HrpA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010222; RNA_helicase_HrpA.
DR   NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF11898; DUF3418; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:SFM74856.1};
KW   Hydrolase {ECO:0000313|EMBL:SFM74856.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          112..275
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          305..472
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1338 AA;  151289 MW;  6A4D8ADB71621635 CRC64;
     MFGVRCEVAK ISGRGDGAFS MLVRSMGTSV KSPLADLRDR LPELMLHDQR RLRRRIEGAR
     KIRDPKALQS VTEEITAEIE AAERRIENRR ANVPEVRYPE NLPVSQRRDD LLAAIRDHQV
     VIVAGETGSG KTTQLPKMCL ELGRGIKGVI GHTQPRRLAA RTVAERVAEE VGTELGDAIG
     YQVRFTERAG EDTLVKLMTD GILLAEIQHD RLLRRYDTLI IDEAHERSLN IDFILGYLKQ
     LLPRRPDLKV IITSATIDPE RFSRHFDDAP VVEVSGRTYP VEVRYRPLLD DSDESEDVVR
     DQTQAICEAV DELCAEGPGD ILVFLSGERE IRDAEDALRQ QNLRNTEILP LYARLSAAEQ
     HRVFQPHSGR RIVLSTNVAE TSLTVPGIKY VIDPGTARIS RYSFRTKVQR LPIEPVSQAS
     ANQRKGRCGR VSEGICIRLY SEADFLARPE FTDPEILRTH LASVILQMTS LGLGEIESFP
     FLEPPDRRQI TDGINLLQEL GALDSAKTEL HKRLTPVGRK LAQLPIDPRL ARMVLEAERN
     GCLREVLVVV AALSIQDPRE RPTDKQQTAD QKHARFVDKD AESDFITYLS MWRYLRTQQK
     ELSSNQFRKL CRADFLNYLR VREWQDLHGQ LRQMVRSMGM TLNDQEADAT RIHQSVLAGL
     LSHIGLKDVE KKSGQPGRGA NEYQGARNAK FAVFPGSSLF KKPPRWVMAA ELVETSRLWA
     RIVARIEPEW VERLAQHLVK RSYSEPHWEK DRAAVVATER VTLYGVPLVV GRKVNYGRID
     PELCRELFIR HALVEGDWET RHAFFHENRA LLDEVEDLEE RARRRDILVD DETLFEFYDQ
     RVGAEVVSGR HFDSWWKKTC REQPDLLNFE KSMLINQQSA AVSDRDYPDT WPQGGLRLAL
     SYQFEPGSDA DGVTAHIPLP VLNQVDPSGF DWQIPGLREE LVTALLKSLP KALRRNFVPA
     PDFAKAVLSR LEPMSAPLLE SLQQGLKQMT GVAVPGTEWD LDKVPDHLKM TFRVVDGKGR
     KLAESKDLDA LKRKLKPKLR AEISAAADDI EQRGLRSWNF GALPRTFEQQ RSGHAVKAYP
     ALVDDGDSVA VRMFDTQEEQ RRALWDGTRR LLLLNLPSPV KSIQRGMSGT TRLVLGGSRY
     GDLNAVLEDC ERCAVDKLMA DNGGPVWDEA AFAALQDKVR AQLGAVTVDA MSKVEQVLVA
     AQRVESALAD RAKVLPAESY ADIRAQLDAL LHPGFVTAAG FARLPDLVRY LRAIEQRLDK
     LQYHPQRDRD WMYQVDEVEE RYRDLLAGVP QGRSPSEALQ HVGWMIEELR VSLFAQAIGT
     AYPVSVKRIH RAMDKLSG
//