ID   A0A1I4TRP6_9EURY        Unreviewed;       453 AA.
AC   A0A1I4TRP6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN   ORFNames=SAMN04488696_2417 {ECO:0000313|EMBL:SFM79349.1};
OS   Methanolobus profundi.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanolobus.
OX   NCBI_TaxID=487685 {ECO:0000313|EMBL:SFM79349.1, ECO:0000313|Proteomes:UP000198535};
RN   [1] {ECO:0000313|EMBL:SFM79349.1, ECO:0000313|Proteomes:UP000198535}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mob M {ECO:0000313|EMBL:SFM79349.1,
RC   ECO:0000313|Proteomes:UP000198535};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
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DR   EMBL; FOUJ01000005; SFM79349.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I4TRP6; -.
DR   STRING; 487685.SAMN04488696_2417; -.
DR   OrthoDB; 214119at2157; -.
DR   Proteomes; UP000198535; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd13143; MATE_MepA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR045070; MATE_MepA-like.
DR   InterPro; IPR048279; MdtK-like.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR   PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        16..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        54..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        238..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        324..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        393..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        421..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   453 AA;  49301 MW;  30CB50307B789A34 CRC64;
     MNNKSEFLGT ESINKLLWKL ATPAIIGLLV QAFYNLVDTF FVGRALGDQS VLGIAGVAVA
     FPLQMLMIAI SIGIGVGGSS VISRMLGSKD VEKAERTLGN VFSYTIIISI LFQILFFFNV
     DTILNLFGAT VDNQIYAKEY AVVILQGTLA FTFGFVLNNL VRAEGNSKIA MNNMVFSGVL
     NIFLDAILMF GFGMGVKGAA LATVLAQLAG TIYLLYYYIT GKSPLKLKLA NLTPKFDLIK
     EITVIGFGSF VMGASNSFMM LVLNNVLAVY GGDLSIAVFG VSIKLIMLIL MPIIGISHGL
     QPIVGYNYGA ENYARVNESV RTSLIITTLF GLVGVTLLSI FPGTFFSMFS TDADLISNGA
     SALRIMVLAS PLIGMNVIGT TLFQSLGKAR PSFFLSMCRQ ILFLIPLVIL LPYYFDLSGV
     WMAFPISDLM AAIISMFLVW REYKFFQHRS SNS
//