ID   A0A1I4U9I2_9EURY        Unreviewed;       584 AA.
AC   A0A1I4U9I2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Chloride channel protein, CIC family {ECO:0000313|EMBL:SFM85460.1};
GN   ORFNames=SAMN04488696_2636 {ECO:0000313|EMBL:SFM85460.1};
OS   Methanolobus profundi.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanolobus.
OX   NCBI_TaxID=487685 {ECO:0000313|EMBL:SFM85460.1, ECO:0000313|Proteomes:UP000198535};
RN   [1] {ECO:0000313|EMBL:SFM85460.1, ECO:0000313|Proteomes:UP000198535}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mob M {ECO:0000313|EMBL:SFM85460.1,
RC   ECO:0000313|Proteomes:UP000198535};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FOUJ01000006; SFM85460.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I4U9I2; -.
DR   STRING; 487685.SAMN04488696_2636; -.
DR   OrthoDB; 89900at2157; -.
DR   Proteomes; UP000198535; Unassembled WGS sequence.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   CDD; cd00400; Voltage_gated_ClC; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR   PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        63..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        158..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        195..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          450..507
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          513..572
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   584 AA;  62438 MW;  324C3BF6B4CB973A CRC64;
     MDKKQANGKI RQNLLQWLQT ESLISNSLAL IVGVLTGFAI VFYDRLLEAS DKLFFGSLPD
     SPGILIIFIP AIGGLIVGII AHTMIHTRRY DIEEIIEATA LRGGRMSPRN AFLEVLASIV
     SIGSGGSVGK EAPVVTAGSG IGALIAQTFK INGNRVKVLI GCGASGGIAA AYNAPLAGVV
     FAVEVILGEL EASSFIPIVI SAVFATMVSS IIFGVHTIEV SSYQFVNPFY ESFLYLFLGI
     FAGITSALLM RALFGTHQIF ESMTIHPAVK PAIGGLFVGL IGYFYPQVFG VGYDVITDAL
     NNGLALKLML VLVVLKIIAF SFTMGSGGSG GSIVPSLFVG AMLGGAYGSI VHGLFPAFTA
     ESGAYALVGM GAVFAGTSRA PLASILILFE LTRDYNMILP IMLACVVSNV ISSSINSESI
     FTEGLHRRGF TIRKGREVDI MEDLLVRDAM KHNVQTVSEN KNVGALVALM QSSRHAGFPV
     LDQNGKLCGI VTLKDVRDKV GHDELEKTIN EIASKDVEIA FPDESLNTVL KRLAAKDIGR
     LPVVSRSDSS KLLGIITRSD IVKLYDKKIL DKVQRLQKEQ TDMI
//