ID A0A1I4UL61_9ACTN Unreviewed; 850 AA.
AC A0A1I4UL61;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Polynucleotide 3'-phosphatase /polynucleotide 5'-hydroxyl-kinase /polynucleotide 2',3'-cyclic phosphate phosphodiesterase {ECO:0000313|EMBL:SFM89739.1};
GN ORFNames=SAMN04487980_100773 {ECO:0000313|EMBL:SFM89739.1};
OS Streptomyces sp. cf124.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761903 {ECO:0000313|EMBL:SFM89739.1, ECO:0000313|Proteomes:UP000198530};
RN [1] {ECO:0000313|EMBL:SFM89739.1, ECO:0000313|Proteomes:UP000198530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF124 {ECO:0000313|EMBL:SFM89739.1,
RC ECO:0000313|Proteomes:UP000198530};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOUV01000007; SFM89739.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4UL61; -.
DR Proteomes; UP000198530; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd07423; MPP_Prp_like; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041780; MPP_PrpE-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR024028; PNKP_bac.
DR InterPro; IPR032380; PNKP_ligase_dom.
DR NCBIfam; TIGR04075; bacter_Pnkp; 1.
DR PANTHER; PTHR12435:SF2; PROTEIN KTI12 HOMOLOG; 1.
DR PANTHER; PTHR12435; UNCHARACTERIZED; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF16542; PNKP_ligase; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:SFM89739.1};
KW Transferase {ECO:0000313|EMBL:SFM89739.1}.
FT DOMAIN 193..379
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 467..845
FT /note="Polynucleotide kinase-phosphatase ligase"
FT /evidence="ECO:0000259|Pfam:PF16542"
SQ SEQUENCE 850 AA; 93558 MW; 38161BC104BBC61D CRC64;
MSETTQQTGE GRTLPVTDLS LVVLIGASGS GKSTFARRHF KPTEIISSDF CRGLVSDDEN
DQSATKDAFD VLHYIAGKRL AAGRRTVVDA TSVQQESRRQ LIELARKHDV LPIAIVLDVP
EDVCAARNAA RTDRADMPRR VIQRHTRELR RSLRHLEREG FRKVHVLRGV EEVDRATIVT
EKRFNDLTHL TGPFDIVGDI HGCASELESL LGKLGYVDGV HPEGRTAVFV GDLVDRGPDS
PGVLRRVMSM VGSGNALCVP GNHENKYGRH LKGRNVQHTH GLAETIAQME GESEEFKQEV
RRFIDGLVSH YVLDGGKLVV CHAGLPEKYH GRTSGRVRSH ALYGDTTGET DEFGLPVRYP
WAEDYRGRAA VVYGHTPVPT ATWLNNTICL DTGAVFGGKL TALRWPEREL VDVPAEKVWY
EPARPLATEA PGGHEGRPLD LADVHGRRVV ETRHAGRVSV REENAAAALE VMSRFAVDPR
LLPYLPPTMA PTATSHVEGY LEHPAEAFAQ YQEDGVARVV CEEKHMGSRA VVLVCRDADA
ARARFGVQGP TGSLYTRTGR PFFDDAARTE LVLARIREAV TAAGLWDELD TDWLLLDAEL
MPWSLKASGL LRTQYAAVGA ASGAVFPGAL TALEGVAARG VDVGELLGRQ RGRAADAAAF
TEAYRRYCWP TEGLDGVRLA PFQILAVQGR SLAALPHDEQ LALLDRLVEY DVSGLLQTTR
RLFVDTADEA SVRAGIDWWL EMTGRGGEGM VVKPVGAVVR STQGRLVQPG IKCRGREYLR
IIYGPEYTRP ENLARLRGRF LNHKRSLALR EYALGLEALD RLAEGEPLWR VHEAVFGVLA
LESEPVDPRL
//
