ID A0A1I4VF67_9ACTN Unreviewed; 1188 AA.
AC A0A1I4VF67;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN04487980_100952 {ECO:0000313|EMBL:SFM99766.1};
OS Streptomyces sp. cf124.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761903 {ECO:0000313|EMBL:SFM99766.1, ECO:0000313|Proteomes:UP000198530};
RN [1] {ECO:0000313|EMBL:SFM99766.1, ECO:0000313|Proteomes:UP000198530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF124 {ECO:0000313|EMBL:SFM99766.1,
RC ECO:0000313|Proteomes:UP000198530};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FOUV01000009; SFM99766.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4VF67; -.
DR Proteomes; UP000198530; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033451; BREX_2_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SFM99766.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SFM99766.1}.
FT DOMAIN 174..285
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 1188 AA; 132483 MW; 30E6299C541BEB6A CRC64;
MLSRADLLRD LRRIRVEIEH DLGTRAPSDP AVDRMRAEYG AAVEQRLTAS TWKAWLQEQV
SQVATGWVLA TVMIRFCEDN GLLGLPFAGR WEPGADDAAN DPILSAVDRL SSHPAMASVF
SRSSHPMWRM RPGPEASRAL VDFWRRRTPE GLLVHDFEDA SRDTRFLADL YMDLSDQARK
SHGLVATPDF VVELIHDLTL EAALHEHGAA PGPAGFRMID PACGSGGFLL AAYTRLCRRW
ADARPGMSPW QRAARALASV HGCDIDPCAV SITRFRLLMA AMDTGRAQTL DDVPDLPLVV
ATGDALLHGP DSDALGPAPG GHVAPPQPTG FGSPTDIDAY AERHGLLRPA SYHVVTSNPP
YLTVKDKALF TAYRDAYESC EGPYTLSVPF TELAFRLALP GPSSGRVGLL TVNSFMKREF
GRRLIERFLP RVRLSHVIDT SGAYIPGHGA PTVILVGRNS VPAPHEPVLL VVGLRGETHL
PQVPAQAPVW QSLRRLAFAP GTTDHWAESY FQERGELSVF PWSLTPSAAR HVLRLMEKGE
RLRERVARIG YAANTGSDDL FCSTPASFRR YGVEEAATIR VLTGSEVRDW SSRAPLEAFF
PRTGNGRELV DLDLCPRHRR RLWPYRTVLA HRRGTNKSSP WYDWHQFALD WDAHPWSIVF
PWVSTHPHFT VLRGGAVPLN SAPVIKLPPS ATESSHLKLL GTLNSSAVCF WLKQVSQSKG
QAHIDTLRGG EAWEKIYEFT AGRLLDLPLP RTMPLAPAEH LDGLATESAD CLSELSAPDT
PLTARTLRSA QDRWFSIRAR MIALQEELDW QVYASYGIVD DAEGLTAVVD PPPLRVGERA
FEIALARRIA SGGTSASWFS DDPEAKWFTR HEAVPTTEVP EHWPAPYRDL VQRRVDAIAQ
NGFLALLEQP EYKHRWIAPD WNATVRDILR ERLLDRCEAD RLWFEAVPTG RRPVARTVRE
LCELLEDDEE FLALLSLYAE LTDADDRSTV SVLLDLLATE HVPQAAPLRY KPSGLTKRRA
WEELWESQLR DDMRGRADTA APQEPPRFTS ADFLKSSYWK QRGKFDLPNE RFTSFASSIS
SLSSTTLLGW AGWDARERTE VLLDILEAEA HAHAHRPEFA LPLLSALTEV LPWVTAVDRG
LGPVRASDGD EQLRESYTRH LARLGLSVQD VRSWRPAAPR RGRPRKGA
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