ID   A0A1I4VYH8_9ACTN        Unreviewed;       528 AA.
AC   A0A1I4VYH8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=NADH:ubiquinone oxidoreductase subunit 5 (Chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit {ECO:0000313|EMBL:SFN06215.1};
GN   ORFNames=SAMN04489713_10179 {ECO:0000313|EMBL:SFN06215.1};
OS   Actinomadura madurae.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=1993 {ECO:0000313|EMBL:SFN06215.1, ECO:0000313|Proteomes:UP000183413};
RN   [1] {ECO:0000313|EMBL:SFN06215.1, ECO:0000313|Proteomes:UP000183413}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43067 {ECO:0000313|EMBL:SFN06215.1,
RC   ECO:0000313|Proteomes:UP000183413};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FOVH01000001; SFN06215.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I4VYH8; -.
DR   STRING; 1993.SAMN04489713_10179; -.
DR   eggNOG; COG1009; Bacteria.
DR   InParanoid; A0A1I4VYH8; -.
DR   Proteomes; UP000183413; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   Gene3D; 1.20.5.2700; -; 2.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   InterPro; IPR003945; NU5C-like.
DR   PANTHER; PTHR42829; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR   PANTHER; PTHR42829:SF2; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01434; NADHDHGNASE5.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183413};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000320};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Ubiquinone {ECO:0000313|EMBL:SFN06215.1}.
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        47..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        138..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        172..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        228..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        256..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        314..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        354..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        393..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        508..527
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          61..327
FT                   /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT                   subunit"
FT                   /evidence="ECO:0000259|Pfam:PF00361"
SQ   SEQUENCE   528 AA;  53367 MW;  D31BB49C95208932 CRC64;
     MTVLPGWPGG LAVDGLSAVL LVTLAVVLAA VLVHAAGEGF GARFHLLMLL FAAAMAVTVT
     ATDLLLLLMG WEVMGATSYA LIGHAWPEAD RVRSANVAFL TTRAADLGLY AAAGFAVAGA
     RSLRFGDLAG AGDPWRDLVA AGVVVAALGK SAQLPFSFWL SRAMAGPSQV SALLHSATMV
     AAGAYLLMRL HPLLAATGWA AGLVSWAGAL TALVLGAVAV AQRDLKQLLA ASTCAQIGFM
     VLAAGAGAVG AGAAQLVAHA AVKSLLFLCA GMWARRDRVV DVAFGVGALA LAGVPPLSLW
     VTKDEVLGGA VERSGGLLAA GLAASVLSAV YAGKALVMLL RPSEGPRVRT VERVPLVALA
     VAAASLGVLG VPAVADGWRR MLGAAGEAGP EPWVVALSGA LAVVTVAGVV AARRVPEPAW
     ALDWLYLERA VTAGVVRPAF AAARALARFD DRVVDGAVRG TARGGRVLAG LAGRRVEFRV
     DGLVGAVGSA ARVLAALARR PQTGQVHLYY AQAAVVLAVL VVVALLAG
//