ID   A0A1I4WA44_9FLAO        Unreviewed;      1047 AA.
AC   A0A1I4WA44;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=SAMN05421741_101126 {ECO:0000313|EMBL:SFN10150.1};
OS   Paenimyroides ummariense.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Paenimyroides.
OX   NCBI_TaxID=913024 {ECO:0000313|EMBL:SFN10150.1, ECO:0000313|Proteomes:UP000199036};
RN   [1] {ECO:0000313|Proteomes:UP000199036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DS-12 {ECO:0000313|Proteomes:UP000199036};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FOVI01000001; SFN10150.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I4WA44; -.
DR   STRING; 913024.SAMN05421741_101126; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000199036; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:SFN10150.1};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          1..466
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          478..736
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         11..18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1047 AA;  120642 MW;  C75F5FF4F13E7230 CRC64;
     MEKKAFTIYN ASAGAGKTHT LVKEYLKILL GYSNKDDAYR NVLAITFTNK AVNEMKSRIV
     SCIYAFTLNE IPLKEYRLLE QIVDETQFTE AYIREKSKKI LKNIIHNYAG FDISTIDKFT
     HKVIRSFAFD LNLPFYFEVS LDTEALLQEA VDALISQAGV DEELTKLLVD FSISKADDDK
     SWDVTNELME IGRLLLNENN KQELEAFENI EMQTFLSLKN WLHDQINQLK NETVVLAQNA
     LQLLETNGID NKSFSGGYFP KHLIGIVEGN YNNANKKYYE FDDIKINKTA KDKEAIEQLI
     PDLLAITKKI YPLFGKVYFY EAFLKNLVPL SLLNSISNEI KRIQNEQQIL SISQFNKIIY
     EELKNQPAPF IYERLGEKYR HFFIDEFQDT SEMQWQNLVP LIDNALSGED DFGKQGSLMI
     VGDPKQAIYR WRGGKAEQFM QLSDGENPFS NPSKATISLD TNYRSFSEVI EFNNGIFKFL
     ANQFNNPAYQ NLYENYSHQN TNPKKGGFVN ISFLNNDLLV DDEVTKDDLY LNEVLKTIEK
     VLNQGFSLGD IVVLTRKSKD GVKVANHLTK NGIRILSSET LLINNATEVQ LLLNLLRFLK
     NNHDREAKAL ILYYVGRFIL KDAKVHDVIV KGMAMDNEID FQNYLKTFGI EINFKELRKN
     NLYVAVELMV SAFIPTKKTE AYVQYFLDLI LERTIKNQST IADFLNYWEQ NYHKLSIPSP
     ENENAVTLMT VHKSKGLEFP VVIYPFADED FSKSRDKIWV DLEENDQLVI PKALVDLKND
     VKMYGETAQR LFDQKKQEEL LDDLNVLYVA LTRAEEQLYI ISNYKRSKTG TLPNTLAAFF
     VTYLEDLGRF SENELNYDFG NPVKVSAEKT DELLKPIVIK SVEKPIDQSV IKIAKREAIM
     WDTKQQHAIE KGNLIHELLA EIITVDDIAF VVKNAVSKGM LPATEETEIS EKITEIVQHA
     ELQPFFNKEN IIYNERPILH ESFKNIKPDR VAISGNKAYI IDYKTGEEQP KYTKQINDYA
     LAIEEMGYEI AKKTLLYIQD DLKIINL
//