ID A0A1I4XAN0_9FLAO Unreviewed; 1236 AA.
AC A0A1I4XAN0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Phosphoribosylformylglycinamidine synthase {ECO:0000313|EMBL:SFN22991.1};
GN ORFNames=SAMN05421738_108185 {ECO:0000313|EMBL:SFN22991.1};
OS Algoriella xinjiangensis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Algoriella.
OX NCBI_TaxID=684065 {ECO:0000313|EMBL:SFN22991.1, ECO:0000313|Proteomes:UP000199149};
RN [1] {ECO:0000313|EMBL:SFN22991.1, ECO:0000313|Proteomes:UP000199149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XJ109 {ECO:0000313|EMBL:SFN22991.1,
RC ECO:0000313|Proteomes:UP000199149};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOUZ01000008; SFN22991.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4XAN0; -.
DR STRING; 684065.SAMN05421738_108185; -.
DR OrthoDB; 9804441at2; -.
DR Proteomes; UP000199149; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02203; PurL_repeat1; 1.
DR CDD; cd02204; PurL_repeat2; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 1.10.8.750; Phosphoribosylformylglycinamidine synthase, linker domain; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 1.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 2.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR010141; FGAM_synthase.
DR InterPro; IPR041609; PurL_linker.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR036921; PurM-like_N_sf.
DR NCBIfam; TIGR01857; FGAM-synthase; 1.
DR PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR Pfam; PF02769; AIRS_C; 1.
DR Pfam; PF18072; FGAR-AT_linker; 1.
DR Pfam; PF13507; GATase_5; 1.
DR SMART; SM01211; GATase_5; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 2.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 2.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 4: Predicted;
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755}.
FT DOMAIN 177..225
FT /note="Phosphoribosylformylglycinamidine synthase linker"
FT /evidence="ECO:0000259|Pfam:PF18072"
FT DOMAIN 435..587
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT ACT_SITE 1077
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1206
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1208
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 1236 AA; 138382 MW; DC4241687D7F39B5 CRC64;
MNQRLFIQKK SNFDIISQKT TIELKNLVPT IVCKVFVIYD LFNIDENQLQ EVQNKVFVDP
VTDNVYKHLS DTLNYSFPDT KNYFATEFLP GQYNQRDDSS EQCLVLMNVE NVTVKSGLLY
VFNNDLTEQD LQKVKDYLIN PIESRVKDLS KMEIPANPEA TEVPTIENFI STDQKGLEEI
YKTYGLSLEM DDLVFIQDYF KSIQRNPTET ELKVLDTYWS DHCRHTTFET EITDIKFNSK
FNTTLQKTFD YYQQIRQELG ITKPIRLMDL ATIMGKYLSR TGVVTNIDVS EEINACSIVV
PIDVDGIEEE WLLQFKNETH NHPTEVEPFG GASTCVGGAI RDPLSGRSYV FQAMRITGAA
NPLEKIEDTL PGKLAQRKIS KEAANGYSSY GNQIGLATTF VKEIYDEGYK AKRMEVGFVA
GAVKKEYVRR EEPVAGDRII LLGGATGRDG VGGASGSSKT HDGLKLDDLS AEVQKGNAIV
ERKIQRLFRN PEVLALIKKC NDFGAGGVSV AIGEIARGIN VDLDKVPLKY AGLNGTELAI
SESQERMAVA VEAKDVDTFI ALAKEENLEA TCVAEVTEDD TMTLVWKGTK IVELDRKFLD
TNGVRKQSKI EVTDEEYKNP FENKSFDKNE FIAMMQELNH ASQKGMVEMF DNNVGRSTIL
NAFGGKTMDT PEDVSVQKFP TDGFTNAVSI AAYGFSPQIS RWSNYHGGYF AVIDSMTKIV
AAGGNYADIR LTFQEYFEKL RDEATRWGKP FSALLGTIEA QRQFGIPAIG GKDSMSGSYQ
DIDVPPTLIS FAVAPSQANK IVQGTLAEKN SKLSVFVPTQ NEDYLLDETN VKAIFDFITS
LNQENVKSMM TVKFGGIAET LANMAFGNEI GFAINTTLDL AKYYPGSIII EHTEDLTIPT
EITQNYHVLG ETNNSVNISF NGDEINLNEL KQQWKETFNS LFPYQSNSEE IVEEKDLKVE
QICFAFADHK VENPKVFIPI FPGTNSEYDS AKAFRREGAI VKTLPFRNLT QQDVEESVEE
FVKEINQANI FFIPGGFSAA DEPDGSGKFI ATVLRNEKIK NAIHQLLERD GLILGVCNGF
QGLIKSGLLP YGKIQELEEN TPTLTFNEIG RHITQLAQVR VNKSHSPWLK GMENQTYWIP
FSHGEGRFVA NDFELEKLID KGQIATQFID LEGKLAGQMP YNPNGSTFAV EGIVSPCGKI
YGRMGHPERY EEGLFKNIPG NGSMNIFKNA VEYFRN
//
