ID A0A1I4YIK0_9FLAO Unreviewed; 752 AA.
AC A0A1I4YIK0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN05660413_00736 {ECO:0000313|EMBL:SFN37430.1};
OS Salegentibacter flavus.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Salegentibacter.
OX NCBI_TaxID=287099 {ECO:0000313|EMBL:SFN37430.1, ECO:0000313|Proteomes:UP000199153};
RN [1] {ECO:0000313|EMBL:SFN37430.1, ECO:0000313|Proteomes:UP000199153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17794 {ECO:0000313|EMBL:SFN37430.1,
RC ECO:0000313|Proteomes:UP000199153};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FOVL01000003; SFN37430.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4YIK0; -.
DR STRING; 287099.SAMN05660413_00736; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000199153; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029464; HSDR_N.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF13588; HSDR_N_2; 1.
DR Pfam; PF02384; N6_Mtase; 2.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000199153}.
FT DOMAIN 28..143
FT /note="Type I restriction enzyme R protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13588"
FT DOMAIN 293..485
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 546..651
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 752 AA; 87598 MW; 5D082CBC4C729513 CRC64;
MKLEIKIDKN KNKIFAPLLD KWIKYSAEEE LKQNFICRLV NVYGYSLSQL GQDVKIKKRY
EADIAIWRNK LDKDENIIPS IIITVECKAE YIKIKESDYS LGYNFASTIN ANFFIAVNLK
ETKIFHIKNE ISNKKIEKLT EIPKADILSD NNKIVKYVNE NKRFTREEFT KLLTRSHNII
RNNDKLSPEA AFDEISKILF MKIMYERSSK EEMIFSKDRF KADELNYEKI IRPSLKKEYP
NFDQDYMQFL FNETKKEFET DGLFEFKDII KIKKNSFEMI VEELEMFNLS DTSDDVKGIA
FEQFLGKTFR GELGQFFTPR TIVDFMIDIL DPQEGETICD PCCGSGGFLI SAFEHIRDKI
DSEINNQIKL LKQQYYNENF EKLSVREQEK IIKLVQEKIH KINQEFDIDD EKSRYHKLSH
YSIYGTDANP RMARTAKMNM IMHGDGHGGV HHNDGLLNVN GIFEERFDVI LTNPPFGARV
EKSLKVTELD LPSVDKLEKY KTRYQNYEEK VVEPLKEWAN YINKKDKSKG KPILDLFEVG
KWSTLTEVLF IERCLNLLKS GGRMGIVLPE GVLNNTNLQK TREFVEGKAK IVLITSIPQD
VFIASGATVK PSLLFFKKFT EEEAKEYKKT FKNAKVEIEA KYAPKTKALK SKLALRGKDA
PTVSEKKQLR KDLKELEVKI ETEIKAKIKT DFDYQIPIAE VDKAGISTTG SKIENELEPL
AKEFTEYRKA NKLWEVKFDT INYNSDKNEV YP
//
