ID A0A1I4Z367_9ACTN Unreviewed; 941 AA.
AC A0A1I4Z367;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=D-lactate dehydrogenase (cytochrome) {ECO:0000256|ARBA:ARBA00038897};
DE EC=1.1.2.4 {ECO:0000256|ARBA:ARBA00038897};
GN ORFNames=SAMN04487980_102065 {ECO:0000313|EMBL:SFN44627.1};
OS Streptomyces sp. cf124.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761903 {ECO:0000313|EMBL:SFN44627.1, ECO:0000313|Proteomes:UP000198530};
RN [1] {ECO:0000313|EMBL:SFN44627.1, ECO:0000313|Proteomes:UP000198530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF124 {ECO:0000313|EMBL:SFN44627.1,
RC ECO:0000313|Proteomes:UP000198530};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; FOUV01000020; SFN44627.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4Z367; -.
DR Proteomes; UP000198530; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR004017; Cys_rich_dom.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748:SF111; D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02754; CCG; 2.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 43..271
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT DOMAIN 535..566
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 941 AA; 100470 MW; 56E73C0F179CC167 CRC64;
MSRTDGLLTP DATLLARLEA AAPGTVAARA SDRLAFAHDA SHYLLVPDAV VTPKDATQVA
ELLRTGAAHG LSLTFRSGGT SLSGQATNDG ILVDTRRHFR GIEILDDGDR VRVQPGATVR
AVNQRLARHG RRLGPDPASE SACTIGGVVA NNSSGMACGT ELNTYRTLES AVLVLPSGTV
LDTGAADADD RLRTLEPRIH EGLVRLRDRV RVNPTSRETI RRLYAIKNTM GYGVNSFVDH
TRPVDILTHL VIGSEGTLAF VAEATFRTVP AHPHAATGLL VFPDLATATG ALPDLVAAGF
ATIELLDATS LRVAQRDPGA TAALRETRVR DHTALLVEHQ EPTAEALRQR VSDTAQILAA
LPLTTTGTLT SEPATRAALW HIRKGLYTAV AGARPSGTTA LLEDIAVPVD RLLPTCAQLT
ELFDLHGYTG GVIFGHARHG NIHFLLNEDF DRPELAERYL AFTDDMVDLV LGHGGTLKAE
HGTGRIMAPY VRRQYGDELY DVMREVKHLL DPHGLLNPGV LLSDDPSVHI RHLKSTPTVE
EEVDRCVECG YCEPVCPSQD LTTTPRRRIV LRREIARART AGDTDLLARL EAESQYDVVD
TCAVDGMCRT ACPVLIDTGD LTRRLRAERR GRAEQKAWAS AARHWDGVTR VAAGALTAAR
AVPAALPGGA TAAGRALLGT DVVPAWSPDL PRGGTRRHPR TAAAAQAVYF PACVSTMFGA
AESGTGKGVG EAFLALCERA GVEVRVPDRI ASLCCGTPWK SKGLTDGHAV MRERVVPVLR
SATDNGALPV VVDAASCTEG LTHLLAKEGI RVMDVVAFVD AEVLPGPPAA RRIPSLVVHP
TCASTQLGLD PALLRVAAAA AEDVIQPEEW RCCAFAGDRG LLHPELTASA TAAEARSLRT
VHATAYASVN RTCELGMTRA TGRPYRHLLE VLEEVTRPTP D
//