ID   A0A1I4Z897_9ACTN        Unreviewed;       288 AA.
AC   A0A1I4Z897;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Tyrosinase {ECO:0000313|EMBL:SFN46486.1};
GN   ORFNames=SAMN04487980_102123 {ECO:0000313|EMBL:SFN46486.1};
OS   Streptomyces sp. cf124.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1761903 {ECO:0000313|EMBL:SFN46486.1, ECO:0000313|Proteomes:UP000198530};
RN   [1] {ECO:0000313|EMBL:SFN46486.1, ECO:0000313|Proteomes:UP000198530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF124 {ECO:0000313|EMBL:SFN46486.1,
RC   ECO:0000313|Proteomes:UP000198530};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
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DR   EMBL; FOUV01000021; SFN46486.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I4Z897; -.
DR   Proteomes; UP000198530; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   4: Predicted;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          55..72
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   DOMAIN          219..230
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
SQ   SEQUENCE   288 AA;  33169 MW;  83DF435E497D670F CRC64;
     MAYTRKDVST LTRSERRRFV GALLQLKQRG EYDEFVRMHI DHYVSDGDGG LRTAHMAPSF
     LPWHRRFVLE LEKALRRIDD TVSVPYWDWT RDRTTTSVPW TADLLGGNGR RSDKRVMTGP
     FAYGTGRWTI TEGLTDIEYL TRDLGYPRNP VGLPTARDLE AALAEPVYDK APWNSVTRGG
     FRNRLEGWGQ GTGNGSWLNH NRVHRWVGGH MVGGASVNDP VFWLHHAFID LQWTRWQRRH
     KGARYLPAKP PARGDSQRGR ILARDERMPP WNVTPGQMEE IGSVYRYA
//