ID A0A1I4ZDR0_9ACTN Unreviewed; 878 AA.
AC A0A1I4ZDR0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:SFN48163.1};
GN ORFNames=SAMN04487980_1021145 {ECO:0000313|EMBL:SFN48163.1};
OS Streptomyces sp. cf124.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761903 {ECO:0000313|EMBL:SFN48163.1, ECO:0000313|Proteomes:UP000198530};
RN [1] {ECO:0000313|EMBL:SFN48163.1, ECO:0000313|Proteomes:UP000198530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF124 {ECO:0000313|EMBL:SFN48163.1,
RC ECO:0000313|Proteomes:UP000198530};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FOUV01000021; SFN48163.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4ZDR0; -.
DR Proteomes; UP000198530; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 335..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 637..808
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 878 AA; 89542 MW; 1AE6B8E7B7619142 CRC64;
MRATGEEERA TAEAGSAGAG VPGAPLRSAV HAASGSRLGD AHPRQEGPTD LRLVPPALAA
WATAALTVHA SPGWVTGVVV VCGVVGAALL ICRQGQGQGQ GLGLGLGRAQ GLGLGREPGR
GRGRGCGLGR GAWSKVSVAV VLLCAGAAAA SAGLHGADLR RGPVPGLVER YARVTADVEL
TSDPRLTRPR VQGHRAAPAA VLLQAEVRRV RSPDGAVVDT RTPVLVIVDV EAGPRRAAWL
SLLPSTRVRV GAHAVPAMVG GDRVAGVLRV RGGGAPVVVD EASAVQRVAG RLRAGLREAT
DGLDADARAL LPGFVVGDTS RVPAELDEAF KATDLTHLLA VSGANFTILL ALFIGPPGLA
QRAERKGLAP RLGIPLRATA LAGGALTLGF VIVCRPDPSV VRAAACGSIA LLAIATGRRR
SLIPALATAV LLLVLYDPWL ARSYGFLLSV LATGALLTLA PRWSAALQRR RVPPRPAEAL
AAAGAAQAVC APVVAVLSAK VSLVAVPCNL LAEFAVAPAT VLGFATLATA PVAMPVAECL
AWCASWPAGW IADIARTGAS LPGAGVDWPG SWAGALLLGL VTVVVVLVGR RLVSRPWLVG
ACLMAFLLVV VQPPPLTRVI TGWPPPGWRF VMCDVGQGDA TVLAAGDGAG VVVDAGPDPV
LVDRCLTSLG ITEIPLVVLT HFHADHVMGL PGVLRGRSVG AIATTGFEEP VEQAAFVRRE
AAARRIPLTR AVAGEERRTG GLTWRVLWPP GDQAAPDGPN DASVTMLVRS AGLTLLLLGD
LEPPGQRELA RSPEAAALGA VDVVKVAHHG SAYQDPGLIR AMAPELALIS VGADNPYGHP
APSTVAALRA GGATVLRTDE DGAVAVAGTA EELLVARD
//
