ID A0A1I4ZRK1_9FLAO Unreviewed; 922 AA.
AC A0A1I4ZRK1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN ORFNames=SAMN05660413_01464 {ECO:0000313|EMBL:SFN52862.1};
OS Salegentibacter flavus.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Salegentibacter.
OX NCBI_TaxID=287099 {ECO:0000313|EMBL:SFN52862.1, ECO:0000313|Proteomes:UP000199153};
RN [1] {ECO:0000313|EMBL:SFN52862.1, ECO:0000313|Proteomes:UP000199153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17794 {ECO:0000313|EMBL:SFN52862.1,
RC ECO:0000313|Proteomes:UP000199153};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; FOVL01000007; SFN52862.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I4ZRK1; -.
DR STRING; 287099.SAMN05660413_01464; -.
DR OrthoDB; 9759785at2; -.
DR Proteomes; UP000199153; Unassembled WGS sequence.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd02016; TPP_E1_OGDC_like; 1.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR InterPro; IPR032106; 2-oxogl_dehyd_N.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR031717; KGD_C.
DR InterPro; IPR042179; KGD_C_sf.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF16870; OxoGdeHyase_C; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000199153};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT DOMAIN 582..775
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 922 AA; 105580 MW; B997ABA4FDF0A8F9 CRC64;
MDRFSFLNAA HTAYFAELYD QYLQYPDSVE PSWRAFFQGF DFGMEQNGIS PDTLEDAPVN
FEEGEIPDHV IKEFRVIRLI DGYRTRGHLF TKTNPVRERR KYSPTLDIEN FDLSKEDLDT
VFNAGDVLGI GPKTLKEIIT HLENVYCDSI GIEYMYIRKP EEISWIQAKL NVNENHPSFS
SEEKKQILKK LNEAVSFESF LHTKYVGQKR FSLEGGESLI PALDSIIEKA AEIGVKEFVM
GMAHRGRLNT LTNIFGKSAK DIFSEFDGKD YEQDIFDGDV KYHLGWSSGR ITDKGKGINI
NIAPNPSHLE AVGPVVEGIT RAKQDRRYEG DTSKVLPILV HGDAAISAQG VVYEVVQMAQ
LDGYKTGGTI HIVVNNQIGF TTNYLDGRSS TYCTDIAKVT LSPVLHVNAD DVEAVVHSIL
FALEFRMKFG RDVFIDLLGY RKYGHNEGDE PRFTQPKLYK AIAKHNNPRD IYAEKLKKEG
VIEEDYVGKL EEEYRAKLDE NLEDSRKEET TRVTPFMYEE WEGFESVRQE GMLEAIDTTV
DIKKLDEVAE TISKLPGDKK FLRKINKIIE GRRQMYFEDN KLDWSMAEHL AYGTLMTEGY
NIRLSGQDSE RGTFSHRHAV LKVEDSEEEI ILHNNIPDRD GDIFIYNSLL SEYGVLGFDY
GYAMTSPRTL TIWEAQFGDF VNGAQIIIDQ YISAAEDKWK LQNGLVMFLP HGYEGQGAEH
SSGRMERFLQ LCARDNMYVA DVTTPANMFH ILRRQMKAGF RKPLIIFTPK SLLRHSKVVS
SKEEFANGSF QPFLDDEEAK VEKIKTLVFC TGKFYYDLLE FKEKNSRDDV ALVRLEQLFP
LPVSEMKEAL KKYKNADDIV WAQEEPRNMG AYGHLLLHFD EAKNFRVCSR KFYGSPAAGS
SVRFKKRHEK VIACVFDKNL EE
//
