ID A0A1I5ABJ9_9ACTN Unreviewed; 761 AA.
AC A0A1I5ABJ9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Oxidoreductase alpha (Molybdopterin) subunit {ECO:0000313|EMBL:SFN59720.1};
GN ORFNames=SAMN04489713_102528 {ECO:0000313|EMBL:SFN59720.1};
OS Actinomadura madurae.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=1993 {ECO:0000313|EMBL:SFN59720.1, ECO:0000313|Proteomes:UP000183413};
RN [1] {ECO:0000313|EMBL:SFN59720.1, ECO:0000313|Proteomes:UP000183413}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43067 {ECO:0000313|EMBL:SFN59720.1,
RC ECO:0000313|Proteomes:UP000183413};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
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DR EMBL; FOVH01000002; SFN59720.1; -; Genomic_DNA.
DR RefSeq; WP_075020427.1; NZ_FOVH01000002.1.
DR AlphaFoldDB; A0A1I5ABJ9; -.
DR STRING; 1993.SAMN04489713_102528; -.
DR eggNOG; COG0243; Bacteria.
DR InParanoid; A0A1I5ABJ9; -.
DR Proteomes; UP000183413; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0030151; F:molybdenum ion binding; IEA:InterPro.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR CDD; cd02787; MopB_CT_ydeP; 1.
DR CDD; cd02767; MopB_ydeP; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR037951; MopB_CT_YdeP.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR010046; Mopterin_OxRdtse_a_bac.
DR InterPro; IPR041953; YdeP_MopB.
DR NCBIfam; TIGR01701; Fdhalpha-like; 1.
DR PANTHER; PTHR43105:SF4; PROTEIN YDEP; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR PIRSF; PIRSF000144; CbbBc; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000183413}.
FT DOMAIN 120..519
FT /note="Molybdopterin oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00384"
FT DOMAIN 644..751
FT /note="Molybdopterin dinucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF01568"
SQ SEQUENCE 761 AA; 82606 MW; 4B521133E3A5E900 CRC64;
MTRKAPAGDF DDSGLEVSKP KAWAAGVPGV TAALRQSYEQ MGVRRTALTL LRVNQKQGFD
CPGCAWPEGD HRHVAEFCEN GAKAVAEEAT TRRITRKFFA AHTVGELAER SDHWLGQQGR
LTEPMVKRAG SEHYEPVSWD EAFRLLAAEL TALESPDEAV FYTSGRTSNE AAFAYQLFAR
AFGTNNLPDC SNMCHESSGS ALSETLGIGK GSVLLDDLYR ADLIFVVGQN PGTNHPRMLS
ALERAKKEGA RIIAVNPLPE AGLMRFKNPQ RPSGVTGQGT VLADRFLQIR LNGDLALFQA
LNRMLLESDA PDAVDHEFLD AHAHGVDAFR EHVLGLDWDD VLEATGLTRG EIAATLGDVL
AAKRIIVCWA MGLTQHRNSV PTIREIVNFL LLRGNIGRPG AGVCPVRGHS NVQGDRTMGI
WEKPKPAFLD ALAAEFGFEP PREHGVDTVD AIRAMRDGRA KVFLGMGGNF VRATPDSAVT
EAALRSCRLT AQVSTKLNRS HAVAGEVALI LPTLGRTERD EQGSGPQFVS VEDSMGMVHA
SRGRLAPASD RLLSEVSIVC RLAQAVLPGS GIGWDAMERD YDVIRDHVSR VVPGFEDYNA
RIREAGGFTL PHAPRDERRF PTATGKANLT VNELEVLRIP EGRLLLQTVR SHDQYNTTIY
GLDDRYRGVK AGRRVVFVNP ADLSGLGLAD GALVDLVSEW SDGTERRAPA FRAVAYPTAP
GCAAAYFPET NVLVPLDSTA EVSNTPTSKS VVIRLEPASS R
//
