ID   A0A1I5AEB7_9FLAO        Unreviewed;       755 AA.
AC   A0A1I5AEB7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Monovalent cation:H+ antiporter-2, CPA2 family {ECO:0000313|EMBL:SFN60773.1};
GN   ORFNames=SAMN05421738_11661 {ECO:0000313|EMBL:SFN60773.1};
OS   Algoriella xinjiangensis.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC   Algoriella.
OX   NCBI_TaxID=684065 {ECO:0000313|EMBL:SFN60773.1, ECO:0000313|Proteomes:UP000199149};
RN   [1] {ECO:0000313|EMBL:SFN60773.1, ECO:0000313|Proteomes:UP000199149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XJ109 {ECO:0000313|EMBL:SFN60773.1,
RC   ECO:0000313|Proteomes:UP000199149};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FOUZ01000016; SFN60773.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I5AEB7; -.
DR   STRING; 684065.SAMN05421738_11661; -.
DR   OrthoDB; 9781411at2; -.
DR   Proteomes; UP000199149; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR   PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02080; TrkA_C; 1.
DR   SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR   PROSITE; PS51202; RCK_C; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        33..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        62..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        88..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        121..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        151..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        222..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        298..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        428..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        456..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        500..521
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        527..545
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          580..664
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51202"
FT   DOMAIN          671..754
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51202"
SQ   SEQUENCE   755 AA;  84847 MW;  68BF77A655C764E8 CRC64;
     MEDHLPRLIT DLGLILCVGA VTTLIFKRIN QPLVLGYIIA GFLVGPHFDY IPSVTEEHNV
     EIWAKIGVIF LLFSLGLEFS FKKLLNVGGS ASITAIVEIV CIVTVGYFVG QLMNWSTMDS
     IFLGGLLASS STTIIIRAFE ELGLKRKKFA NVVFGILIVE DIVVILLMVM LSTMAVSQQF
     NGGEMINSFI KLGFFLAVWF IGGIFIIPSF LRSIKKYLDD ETLLIISIAL CLAMVYIADS
     AGFSIELGAF VMGSILAETV YAEKIEHNFK SVKDLFATIF FISIGMMIDP ISMYEHKWAI
     LIITLVTIFG KLIFTSIGAI ISGQPLKQSV QVGMSMAQIG EFAFIVAGLG LSLGVTSDFL
     FPVAVGVSAI TTFTTPYLIK SSEPVYNFLV KILPAKFVKG IDTYSSDTQH IQDENKWNKI
     IKQTITTIFV NGIIIIAVTL IIKNTLLFLL TDWFSYFGSS LVCVILTIII CIPFIWAIIG
     NRPKREIIRE FWDESNYNRA PIIGIIIIRI LLVLAAVIFI YNQFFSSKLA SIILAVGLIV
     FMYLLSKHFD QFYNYIQKKF IYNLNEREIL TQKAAQKKID DKFQYTWDNT HISDMIVPQN
     ANFIGVKLGD LDWRTKFHIN IAYIKRGDRI LQMPNSESVL YPFDKIGIIG NDEQIQRFEK
     YLQIIGETPP ENNQVKNTDN ITLDKVVVPQ DFCVLEHKSV GWVKDTSGGI VVSIERDGAI
     LYNPDRNVAI ELGDYLTIVA DKKNLKSFIQ LYHLK
//