ID   A0A1I5B2B8_9FLAO        Unreviewed;       971 AA.
AC   A0A1I5B2B8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE            EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN   ORFNames=SAMN04487989_102436 {ECO:0000313|EMBL:SFN68761.1};
OS   Bizionia echini.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Bizionia.
OX   NCBI_TaxID=649333 {ECO:0000313|EMBL:SFN68761.1, ECO:0000313|Proteomes:UP000198705};
RN   [1] {ECO:0000313|EMBL:SFN68761.1, ECO:0000313|Proteomes:UP000198705}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23925 {ECO:0000313|EMBL:SFN68761.1,
RC   ECO:0000313|Proteomes:UP000198705};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC         residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC         Evidence={ECO:0000256|ARBA:ARBA00001231};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 3 family.
CC       {ECO:0000256|ARBA:ARBA00005336}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FOVN01000002; SFN68761.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I5B2B8; -.
DR   STRING; 649333.SAMN04487989_102436; -.
DR   OrthoDB; 9805821at2; -.
DR   Proteomes; UP000198705; Unassembled WGS sequence.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.40.50.1700; Glycoside hydrolase family 3 C-terminal domain; 1.
DR   Gene3D; 3.20.20.300; Glycoside hydrolase, family 3, N-terminal domain; 1.
DR   InterPro; IPR001466; Beta-lactam-related.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR019800; Glyco_hydro_3_AS.
DR   InterPro; IPR036881; Glyco_hydro_3_C_sf.
DR   InterPro; IPR001764; Glyco_hydro_3_N.
DR   InterPro; IPR036962; Glyco_hydro_3_N_sf.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR30480:SF13; BETA-HEXOSAMINIDASE; 1.
DR   PANTHER; PTHR30480; BETA-HEXOSAMINIDASE-RELATED; 1.
DR   Pfam; PF00144; Beta-lactamase; 1.
DR   Pfam; PF00933; Glyco_hydro_3; 1.
DR   PRINTS; PR00133; GLHYDRLASE3.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF52279; Beta-D-glucan exohydrolase, C-terminal domain; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   PROSITE; PS00775; GLYCOSYL_HYDROL_F3; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..971
FT                   /note="beta-N-acetylhexosaminidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5011647671"
FT   DOMAIN          45..361
FT                   /note="Glycoside hydrolase family 3 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00933"
FT   DOMAIN          593..950
FT                   /note="Beta-lactamase-related"
FT                   /evidence="ECO:0000259|Pfam:PF00144"
SQ   SEQUENCE   971 AA;  109138 MW;  215FF019B2B04319 CRC64;
     MRLLFFAVLF IALKPVLFAQ TTDPLLTPDA NEQLKWVDSI YASMTLDEKI GQLFMVQAFS
     NKGLRHENII SQMVTNNHIG GIIFSKGDPV NQARFNNELQ DVAKVPLLVG MDAEWGLSMR
     LDSTYAFPWN MTLGAIKDNQ LVAKAGYHIG EHCKRLGVHF NFAPDIDINT NPKNPIIGNR
     SFGEDRENVT EKAAVFMQGM HDAGILSSAK HFPGHGDTDT DSHKALPTID FDLKRIDSIE
     MYPYKRLIKE GVSSVMVAHL NVPALEPENG LPTSLSKHVI TDILKDQLGF KGLIFTDALN
     MKGVADFDSP GAIDLAAFQA GNDILLISED VPKAIDKIRE AYNAGDITEE RLAHSVKKIL
     KAKYKVELNK YIPVDLDNLI SDLNRPEDDV LYEKLMENAI TVVKNKGDVL PIRNLETKKI
     AYVKLGDDDG TDFLKGLQKY GKVHEVIGDN LDEVIEKLKA YNTVIIGFHR SNDTPWKSFE
     FSDKELVWLY EIARTNTVIL DVFVRPYALL DVKTLENVES LVVSYQNSPK AQDASAQVIF
     GAVQAQGNLP VSIGNGFVVG NGITLSSLSR LGYTTPERVG MSSEKLHKID AVAQRAVDEK
     MTPGIQLLVA RKGKVIYNKN FGKHTYDTDS EPVKFNDIYD VASLTKILAT LPLLMELEEK
     GIVSLDTKLS KILPEYTNSN KKDITLKQML SHYARLSPWI PFYFATLDSN KLPDPKYYRK
     EYGGKFTVKV ANELYMRADY QDSMQKIIRE SDLLKTLRYR YSDLPYYILK KYLEKYYEKG
     LDELVQDHFY QSLGANHTTY NPNTKFSDIN IVPSEMDDYY RYQKVQGYVH DMGAAMQGGV
     GGHAGIFSNA NDVAKIMQTY LQKGFYGGKR YFKSVTLDKF NTCFYCDKDN RRGIGFDKPQ
     LGESGPTCGC VSMTSFGHSG FTGTYAWADP EEEIVYVFLA NRTYPNAGAN TLLKENIRTD
     IQALIYEAII D
//