ID A0A1I5B6X5_9FLAO Unreviewed; 874 AA.
AC A0A1I5B6X5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN05660413_02215 {ECO:0000313|EMBL:SFN70370.1};
OS Salegentibacter flavus.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Salegentibacter.
OX NCBI_TaxID=287099 {ECO:0000313|EMBL:SFN70370.1, ECO:0000313|Proteomes:UP000199153};
RN [1] {ECO:0000313|EMBL:SFN70370.1, ECO:0000313|Proteomes:UP000199153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17794 {ECO:0000313|EMBL:SFN70370.1,
RC ECO:0000313|Proteomes:UP000199153};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FOVL01000013; SFN70370.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5B6X5; -.
DR STRING; 287099.SAMN05660413_02215; -.
DR Proteomes; UP000199153; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000199153}.
FT DOMAIN 692..708
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 618..625
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 874 AA; 99163 MW; A5F16FA06A5FED00 CRC64;
MSAKKSPKVT PLMKQYNAIK AKYPDALLLF RVGDFYETFG EDAVKTARIL NIVCTNRNNG
SERTELAGFP HHSLNTYLPK LVKAGERVAI CDQLEDPKMT KTIVKRGVTE LVTPGVAMSD
EVLQSKSNNF LCAVHFGKKI LGVSFLDVST GEFLTAQGNT EYIDKLLQNF SPSEVLIQKK
FKKDFAASFG EDFHCFYLDD WVFKSDFAYE TLNEHFQTKS LKGFGVEHLE EGIIASGAVL
HYLAETRHDK LQHINAVNRI AEEEYVWMDR FTIRNLELYH STAANAVTLL DVIDKTISPM
GGRLLKRWLA LPLKNTEKIR QRHQVVEFLL ENPEVLEEIQ QHIKQISDLE RLISKVATTK
VSPREVNQLK HSLDAVAPIK ALALESENEA IKVIGDQLND CNLLRDKIGQ SLNEEAPVNI
LKGNCIKEGF SEELDELRKI AFSGKDYLNN MLKRETRATG ISSLKIGNNN VYGYYIEVRN
THKDKVPEEW VRKQTLVNAE RYITEELKEY ETKILGAEEK ILHLEQQLFA QLVQWMGDYI
QPVQQNAQLI ARMDCLASFA LQARTENYCK PEIMEGYELE IREGRHPVIE KQLPIGENYV
TNNLHLDREN QQVIMITGPN MSGKSAILRQ TALIVLMAQM GSFVPAKSAE VGLVDKIFTR
VGASDNISMG ESTFMVEMNE TASILNNISD RSLVLLDEIG RGTSTYDGIS IAWAISEYLH
EHPARPKTLF ATHYHELNEM CDTFERIKNF NVSVKELKDN VLFLRKLVPG GSEHSFGIHV
ARMAGMPQQV LHRANKIMEK LEKSHSMEDS GEILKKSAED ELQLSFFNLD DPLLEELKDE
LLQIDIDTLT PVEALMKLNE IKRMLAGKAK KART
//
