ID   A0A1I5B885_9CLOT        Unreviewed;      1259 AA.
AC   A0A1I5B885;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Multidrug efflux pump subunit AcrB {ECO:0000313|EMBL:SFN70923.1};
GN   ORFNames=SAMN04488695_10466 {ECO:0000313|EMBL:SFN70923.1};
OS   Proteiniclasticum ruminis.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Proteiniclasticum.
OX   NCBI_TaxID=398199 {ECO:0000313|EMBL:SFN70923.1, ECO:0000313|Proteomes:UP000181899};
RN   [1] {ECO:0000313|EMBL:SFN70923.1, ECO:0000313|Proteomes:UP000181899}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ML2 {ECO:0000313|EMBL:SFN70923.1,
RC   ECO:0000313|Proteomes:UP000181899};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOVK01000004; SFN70923.1; -; Genomic_DNA.
DR   RefSeq; WP_074911817.1; NZ_FOVK01000004.1.
DR   AlphaFoldDB; A0A1I5B885; -.
DR   STRING; 398199.SAMN05421804_107122; -.
DR   eggNOG; COG0841; Bacteria.
DR   OrthoDB; 9757876at2; -.
DR   Proteomes; UP000181899; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 2.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 3.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF0; SWARMING MOTILITY PROTEIN SWRC; 1.
DR   Pfam; PF00873; ACR_tran; 2.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000181899};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        562..581
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        588..608
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        614..639
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        659..679
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        699..718
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        739..764
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1085..1104
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1111..1131
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1137..1162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1183..1204
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1216..1240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   COILED          239..280
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1259 AA;  135816 MW;  F27B97B308B45F5A CRC64;
     MISKYSVKKP YTVVVAVILT ILLGVISFLG MKTDLLPSLD LPFVVVITPY PGASPEKVEQ
     LVTRPLEAAL GTSSGLSSMN STSSENSSLI FLEFVQGTNM DSVMIELSGS LDQVKARLEE
     GIGTPILMRI SPDMLPIVVA SVDVEGMSLD ELSAFTEEEI MPSFERLDGV AAVTGSGLVA
     SQLEVSLLPE KIAVLNERVK NHLLAELAKN ETELKNAMTS LESGQKTLAA ESQNQKEQVA
     KASVELSSAM ANLNALLAEE AKLTAEKAAL EATRDQLRSV LDMNAIFTAL FPEGTENLTL
     EDLQLILSSM ESGAPEAMEG MTEEMISGLS DQVQEAVKTL VAVELELSSL NVRQMTLSAM
     KPELQKGLNQ SKAAAEQLEA GKITMAVELA KAEVQMATGK TELEKGLAAF EDAKKQALES
     ADLTGILTEE MVKNILMAQN FSMPAGYIEE GDGQILVKVG DAFEKPVDIR DLVVFSMEPI
     GDIKLNEVAE VEKRDNSDEI YTKINGNNGV LLTFQKQSTS STAEVSDLIH SEIEKLEGLH
     ENLSITPMMD QGEYIDMTTS SVMENLLFGG ILAILVLILF LRDLKPTFVI ALSIPISLTF
     AVVLMYFSNV TLNVISLSGL ALGVGMLVDN SIVVIENIYR LRKEGMPAKE AAITGANEVA
     GAIFASTLTT VSVFLPIVFT EGISRQLFTD MGLTIGYSLI ASLIVALTLV PSMGATMLKT
     TSEKEHKWFD KTVQRYEKLL GIALKYKMIV VLFAVGLLGL SIYLTTTMGT AFIPEVDSPQ
     MSASYEASEG LETDEVNALN DDIVERILSI DAVETVGVMR GGSGFMGFGG GGGTNNGDAS
     TFYILLKDER SLSNKEVEQL IYENTEDLGG EMSVSASNMD ISAFGGSGIQ VKVEGFDPDE
     MAVLAKDVAK VLSETEGTED VTTGLEDAGE EIRITVDKVK AIREGLTVAQ VFAEVSKALS
     QEMTATQLTE MGASYPVVLL KPIQEGLNRN TVGDLSMVVQ QRDGSEKTVI LKDIATVEVT
     ESVQSISREN QSRYMTVSAS IKDGYNIGLV GREVEEKFAS FEVPEGYKIT FEGENETIND
     TLGDLVIMIT LAVVFIYLIM VAQFQNLLSP FIVLFTLPLA FTGGLLLLYI AGMELSIIAM
     LGFLVLAGVV VNNGIVFVDY VNQLRERGIE KREAILRTGA TRIRPIIMTA LTTILALTTL
     ALGYGSGAEM MQPMAVVTVG GLTYATLLTL FVVPVLYDLF VRVKKRNSLK SENSEEVSS
//