ID A0A1I5BBN2_9BRAD Unreviewed; 302 AA.
AC A0A1I5BBN2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=SAMN05216330_101358 {ECO:0000313|EMBL:SFN72123.1};
OS Bradyrhizobium sp. Ghvi.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Bradyrhizobium.
OX NCBI_TaxID=1855319 {ECO:0000313|EMBL:SFN72123.1, ECO:0000313|Proteomes:UP000198509};
RN [1] {ECO:0000313|EMBL:SFN72123.1, ECO:0000313|Proteomes:UP000198509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ghvi {ECO:0000313|EMBL:SFN72123.1,
RC ECO:0000313|Proteomes:UP000198509};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOVU01000001; SFN72123.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5BBN2; -.
DR STRING; 1855319.SAMN05216330_101358; -.
DR OrthoDB; 9812907at2; -.
DR Proteomes; UP000198509; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981:SF7; 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 2..157
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 163..283
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 169
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 302 AA; 31301 MW; EDFA5251ECEC03C5 CRC64;
MDIGFIGLGN MGFPMARRLI EAGHKLVVFD TRKEAVDKLV ARGASAATSP RDVADEVETV
MASLPSLQAS LEVATGANGV IEGSRAKRFI DLSTVGSQMA SKIHALLAKR NIVQIDCPVS
GGVGGAEKGT LAVMVSGPKA EFELLKPALD VIGKVFFIGE KPGAAQTMKL ANNFLSATAI
VATSEAVVMG VKAGLDPAVM IDVINAGSGM NTASRDKFPR SVLPRTFDFG FATGLMVKDV
RLALEEMKQL GLSMEVADAV GRLWETVIAA EGAESDFTAA IKPIEKKAGV VVGGKTGGLA
GK
//
