ID A0A1I5BNY9_9PROT Unreviewed; 482 AA.
AC A0A1I5BNY9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=SAMN05216386_1752 {ECO:0000313|EMBL:SFN76326.1};
OS Nitrosospira briensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosospira.
OX NCBI_TaxID=35799 {ECO:0000313|EMBL:SFN76326.1, ECO:0000313|Proteomes:UP000183107};
RN [1] {ECO:0000313|Proteomes:UP000183107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nsp8 {ECO:0000313|Proteomes:UP000183107};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
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DR EMBL; FOVJ01000003; SFN76326.1; -; Genomic_DNA.
DR RefSeq; WP_074796718.1; NZ_FOVJ01000003.1.
DR AlphaFoldDB; A0A1I5BNY9; -.
DR STRING; 1266925.GCA_000619905_01907; -.
DR OrthoDB; 9806359at2; -.
DR Proteomes; UP000183107; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR049577; GMPP_N.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Isomerase {ECO:0000313|EMBL:SFN76326.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:SFN76326.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000183107};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SFN76326.1}.
FT DOMAIN 6..296
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 325..475
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 482 AA; 52958 MW; 0EBAFE9EF48421F0 CRC64;
MQSLIPVVLS GGSGTRLWPL SREKYPKQLL PLIGEDSLLQ ATLRRMEGLT DVQLGAPLVV
CNEEYRFVIA EQLRLMGTKG AILLEPVGRN TAPALTLAAL ASMRDGEDPT LLVMPADHVI
MDVASFQGVV RLAMPLATEG KIVTFGITPD SPETGYGYIQ AGETLGRDGA SRIARFVEKP
DLATAQAYLD AGSYFWNSGL FMMRASVWLS AIGYCRPDIL TACRAAWDQG SADGDFLRVG
KEAFMRCPSD SIDYAVMERI AGCESSLPVG AFVPLSAGWS DVGAWDSLWQ VLPKDDQGNV
SQGDALLENC HNMLVMAEHR LVACIGVEDM VVVETPDAVL VSHMSKTQHV KRIVDRLKRE
GRPESELHRK VFRPWGWYDG VDSGKRFQVK RIVVKPGAAL SLQMHHHRAE HWIVVSGTAQ
VTRGDASYLV SENESTFIPL GTRHRLENPG CVPLEMIEVQ SGSYLGEDDI VRFDDVYGRN
ES
//
