ID A0A1I5CMJ2_9RHOB Unreviewed; 320 AA.
AC A0A1I5CMJ2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN04487859_110115 {ECO:0000313|EMBL:SFN88133.1};
OS Roseovarius lutimaris.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Roseovarius.
OX NCBI_TaxID=1005928 {ECO:0000313|EMBL:SFN88133.1, ECO:0000313|Proteomes:UP000198599};
RN [1] {ECO:0000313|EMBL:SFN88133.1, ECO:0000313|Proteomes:UP000198599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 28463 {ECO:0000313|EMBL:SFN88133.1,
RC ECO:0000313|Proteomes:UP000198599};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.
CC {ECO:0000256|ARBA:ARBA00025705}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879, ECO:0000256|RuleBase:RU003960}.
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DR EMBL; FOVP01000010; SFN88133.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5CMJ2; -.
DR STRING; 1005928.SAMN04487859_110115; -.
DR OrthoDB; 9815856at2; -.
DR UniPathway; UPA00262; UER00211.
DR Proteomes; UP000198599; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd11642; SUMT; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 74..283
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 320 AA; 34446 MW; 902D41DE5DFD01FB CRC64;
MKHFPIYRSL MAAVSLRRAV AIRLLGRRHR DFRAECDFTV DPRAIEMGAK SEVKNDMQAT
LNKHKTVEGH QGHVAFVGAG PGDPELLTLK ACKALEAADV VIHDRLVTPE ILELARREAV
LIDAGKEGFG PSMSQDDINA LIVTHAKTGA QVVRLKGGDP TVFGRLDEEI DAVTEAGIGW
HVVPGITAAS ASVAAIGQSL TKRGRNASAR LLTGHDMKGF ADHDWRALAQ PGEVAAIYMG
KKSARFIQGR LIMQGADRAT PVTVIENASR PDQRILATTL DALPSALTEA DITGPALMFY
GLSPRETQAG LTRIQQQELA
//
