ID   A0A1I5DZQ6_9ACTN        Unreviewed;       434 AA.
AC   A0A1I5DZQ6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=ferredoxin--NADP(+) reductase {ECO:0000256|ARBA:ARBA00013223};
DE            EC=1.18.1.2 {ECO:0000256|ARBA:ARBA00013223};
GN   ORFNames=SAMN04487980_104912 {ECO:0000313|EMBL:SFO04686.1};
OS   Streptomyces sp. cf124.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1761903 {ECO:0000313|EMBL:SFO04686.1, ECO:0000313|Proteomes:UP000198530};
RN   [1] {ECO:0000313|EMBL:SFO04686.1, ECO:0000313|Proteomes:UP000198530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF124 {ECO:0000313|EMBL:SFO04686.1,
RC   ECO:0000313|Proteomes:UP000198530};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2
CC         oxidized [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:20125, Rhea:RHEA-
CC         COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349; EC=1.18.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001005};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR   EMBL; FOUV01000049; SFO04686.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I5DZQ6; -.
DR   Proteomes; UP000198530; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   PANTHER; PTHR11938; FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR11938:SF91; NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF51971; Nucleotide-binding domain; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          22..188
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
SQ   SEQUENCE   434 AA;  45978 MW;  6F009FE8090F9F34 CRC64;
     MKTPAETAPN RAAAATGDGV PFRVAVVGAG PSGCYTAQAL RKGQPDIEIV VLDSLPTPFG
     LVRYGIAPDH QGAKAVSRQF DRVFAQPGVE FVGNVSVGTD VGFESLLENF HAVVLATGLG
     ADRQLGIDQD PDARVVGAGD LIRLLNSDPD ARLRHRRDGL ESLGAEVVIL GTGNVAVDVA
     RLLSKSDLDF IASDIDDGAL RAVAPHPVRT IHILGRCPSH LAKWDASMVK ELAQVVGVHV
     SVDGTPLLGE PAVSPRTTVN VRFERVPASI RRHDDRIRVT THRAGDSGRV DHLDADTVIT
     ALGFDSSAAH VTRFGGLGAP NVFRVGGPAT GRLGNLAENR KLAADTAKDV LAFLRGQEPQ
     HRAGLDGLRD RLPASAVSFE AWQRIDEAEI RRARPDRCRT KFTTRDELLA AAAGSDALPF
     IPLATTGPAA TQEN
//