ID A0A1I5E106_9RHOB Unreviewed; 377 AA.
AC A0A1I5E106;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Membrane fusion protein, multidrug efflux system {ECO:0000313|EMBL:SFO05195.1};
GN ORFNames=SAMN04487859_11451 {ECO:0000313|EMBL:SFO05195.1};
OS Roseovarius lutimaris.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Roseovarius.
OX NCBI_TaxID=1005928 {ECO:0000313|EMBL:SFO05195.1, ECO:0000313|Proteomes:UP000198599};
RN [1] {ECO:0000313|EMBL:SFO05195.1, ECO:0000313|Proteomes:UP000198599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 28463 {ECO:0000313|EMBL:SFO05195.1,
RC ECO:0000313|Proteomes:UP000198599};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; FOVP01000014; SFO05195.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5E106; -.
DR STRING; 1005928.SAMN04487859_11451; -.
DR OrthoDB; 9816569at2; -.
DR Proteomes; UP000198599; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..377
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011464867"
FT DOMAIN 33..352
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 51..284
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 98..170
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 377 AA; 40144 MW; 2393793515DF411E CRC64;
MPSVSRFFVS LVASLALAPM VGLAQQSQGP TSVTVVTVQP QSVTLTSTLP GRVAASAEAE
VRPQVNGIIT ERMFEEGADV DVNAPLYQID TVTYEASVRQ ARATVAQAEA QLRAAEREAV
RLQELQARNV ASEQALDEAT ATRDSAAAGL ELAQAQLNSA EIELSRTTIR ARLSGRIGLS
QTSQGALVTA SQAEPLAVIR RIDPVYVDVT QSAADLLRWR RGETERALAG ADGTVRLKLA
DGSIYGETGQ LKAAEPNVDP LTGVVTLRMQ FSNPDMLLLP GMYVQVDLPV EVAENVFLVP
QEGVIRDRRG RPLAWVVNGD GVVEQREITI LQDRGSDWVV DSGLEAGEQV IVAGFQKTAP
GATVAPQERA ATSAPSE
//
