ID A0A1I5E6T4_PARPN Unreviewed; 1516 AA.
AC A0A1I5E6T4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Glutamate synthase (NADPH) large subunit {ECO:0000313|EMBL:RKS52691.1};
GN ORFNames=BDE18_2023 {ECO:0000313|EMBL:RKS52691.1};
OS Paracoccus pantotrophus (Thiosphaera pantotropha).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=82367 {ECO:0000313|EMBL:RKS52691.1, ECO:0000313|Proteomes:UP000273626};
RN [1] {ECO:0000313|EMBL:RKS52691.1, ECO:0000313|Proteomes:UP000273626}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35512 / DSM 2944 / CIP 106514 / LMD 82.5 / NBRC 102493 /
RC NCCB 82005 / GB17 {ECO:0000313|Proteomes:UP000273626};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- COFACTOR:
CC Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC Evidence={ECO:0000256|ARBA:ARBA00001927};
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC -!- PATHWAY: Energy metabolism; nitrogen metabolism.
CC {ECO:0000256|ARBA:ARBA00004802}.
CC -!- PATHWAY: Nitrogen metabolism. {ECO:0000256|ARBA:ARBA00004909}.
CC -!- SIMILARITY: Belongs to the glutamate synthase family.
CC {ECO:0000256|ARBA:ARBA00009716}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKS52691.1}.
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DR EMBL; RBLI01000001; RKS52691.1; -; Genomic_DNA.
DR Proteomes; UP000273626; Unassembled WGS sequence.
DR GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0015930; F:glutamate synthase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006537; P:glutamate biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00982; gltB_C; 1.
DR CDD; cd00713; GltS; 1.
DR CDD; cd02808; GltS_FMN; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR Gene3D; 2.160.20.60; Glutamate synthase, alpha subunit, C-terminal domain; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR002489; Glu_synth_asu_C.
DR InterPro; IPR036485; Glu_synth_asu_C_sf.
DR InterPro; IPR006982; Glu_synth_centr_N.
DR InterPro; IPR002932; Glu_synthdom.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR PANTHER; PTHR11938; FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE; 1.
DR PANTHER; PTHR11938:SF133; GLUTAMINE AMIDOTRANSFERASE TYPE-2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00310; GATase_2; 1.
DR Pfam; PF04898; Glu_syn_central; 1.
DR Pfam; PF01645; Glu_synthase; 1.
DR Pfam; PF01493; GXGXG; 1.
DR SUPFAM; SSF69336; Alpha subunit of glutamate synthase, C-terminal domain; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
PE 3: Inferred from homology;
KW 3Fe-4S {ECO:0000256|ARBA:ARBA00023291};
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Glutamate biosynthesis {ECO:0000256|ARBA:ARBA00023164};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 35..432
FT /note="Glutamine amidotransferase type-2"
FT /evidence="ECO:0000259|PROSITE:PS51278"
FT REGION 912..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1516 AA; 165605 MW; E9F6A73CE8131EAF CRC64;
MKDCEQMSWE QQEQARRDWM AEHSLYRAED EHSSCGVGLV VSIDGKASRK VVESGITALK
AIWHRGAVDA DGKTGDGAGI HVQIPVPFFY DQVRRTGHEP DHDKLIAVGQ VFLPRTDFAA
QERCRTIVES EVLRMGHYIY GWRHVPVNTA VLGEKANATR PEIEQILIRC DKDIDDEQFE
RELYIIRRRI EKAAVAAQIA GMYICTLSCR SIIYKGMMLA EQVAEFYPDL KDERFESAFA
IYHQRYSTNT FPQWWLAQPF RMLAHNGEIN TLKGNSNWMK SHEIRMASRT FGEMAEDIKP
IIPGGSSDSA ALDAVFEVLV RSGRNAPMTK TILVPEAWSK ATTDMPKAWA DMYAYCNSIM
EPWDGPAALA MTDGRWVCGG LDRNGLRPLR YVVTGDNLLI AGSEAGMVPV NETAVREKGA
LGPGQMIAVD MAEGKLYHDR EIKDHLAASQ PFGDWVEKVV QPSELMAKLP ETALHSGEEL
HRRQIAVGYT VELVEQMLVP MAEDAKEALA SMGDDTPPAV LSRQFRPLSH YFRQNFSQVT
NPPIDSLRES RVMSLRTRFG NLKNVLEESS THAEITMLES PFLANGEFEE LTRMFQGQAT
QIDCTFPANG GPDALAEALA RIRAEAEDAV RSGNGHIILT DEGISANRVG VPMILATSAV
HSWLTRKGLR TFCSLNVRAS ECVDPHDFAV LIGCGATTVN PYLAQDTLAE RIERGLLDGN
LIDIMTRYRE AIDAGLLKIM AKMGISVLSS YRGGLNFEAV GLSRAMVAEY FPGMQSRISG
IGLHGLQAKL EEAHAKGFRA PLVDLLPVGG FYKARRSGEK HAWEANTMRL LQLACEKASY
DVWKQFTATM RANPPIHIRD LLDIKPLGKP VPLEEVESIT SIRKRFVTPG MSLGALSPEA
HMTLNIAMNR IGAKSDSGEG GEDPAHSHPL PNGDNPCAKI KQVASGRFGV TAEYLNACEE
LEIKVAQGAK PGEGGQLPGM KVTDLIARLR HSTKGVTLIS PPPHHDIYSI EDLAQLIYDL
KQINPRAKIT VKLVASSGVG TIAAGVAKAK ADVILISGHN GGTGASPATS IKFAGLPWEM
GLTEAHQVLA MNRLRDRVTL RTDGGLRTGR DIVMAAMMGA EEYGIGTAAL IAMGCIMVRQ
CQSNTCPVGV CTQDEKLRAM FNGSADKVVN LITFYATEVR EILASIGARS LDEVIGRADL
LTQVSRGDKS LDDLDLNPLL ITVDGSEKIV YDRSKPRNAV PDTLDAEIIR DAGRFFSDGE
KMQLSYAVRN TQRTVGTRTS SMIVQTFGMR NKLQPDHLTV RLTGSAGQSL GAFAAPGLKI
EVSGDANDYV GKGLSGGTIV VRPPMGSPLK AAENTIIGNT VLYGATDGYL FAAGRAGERF
AVRNSGAKVV IEGCGSNGCE YMTGGVAVIL GRIGANFGAG MTGGMAYLYD PEGLARDYIN
AETLVLCPVT QAHWEGELKG LIERHYQETR SRRAEEILQN WEDEKANFLQ VCPREMLPHL
KHPIAPVEDL AAVPAE
//