ID A0A1I5E9M4_9FIRM Unreviewed; 578 AA.
AC A0A1I5E9M4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Histidinol-phosphate aminotransferase {ECO:0000313|EMBL:SFO07781.1};
GN ORFNames=SAMN04489757_10885 {ECO:0000313|EMBL:SFO07781.1};
OS Anaerocolumna aminovalerica.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaerocolumna.
OX NCBI_TaxID=1527 {ECO:0000313|EMBL:SFO07781.1, ECO:0000313|Proteomes:UP000198806};
RN [1] {ECO:0000313|EMBL:SFO07781.1, ECO:0000313|Proteomes:UP000198806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1283 {ECO:0000313|EMBL:SFO07781.1,
RC ECO:0000313|Proteomes:UP000198806};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the CobH/CbiC family.
CC {ECO:0000256|ARBA:ARBA00009774}.
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DR EMBL; FOWD01000008; SFO07781.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5E9M4; -.
DR STRING; 1527.SAMN04489757_10885; -.
DR OrthoDB; 9813612at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000198806; Unassembled WGS sequence.
DR GO; GO:0016993; F:precorrin-8X methylmutase activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00609; AAT_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.50.10230; Cobalamin biosynthesis CobH/CbiC, precorrin-8X methylmutase; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR003722; Cbl_synth_CobH/CbiC.
DR InterPro; IPR036588; CobH/CbiC_sf.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR43588; COBALT-PRECORRIN-8 METHYLMUTASE; 1.
DR PANTHER; PTHR43588:SF1; COBALT-PRECORRIN-8 METHYLMUTASE; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF02570; CbiC; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF63965; Precorrin-8X methylmutase CbiC/CobH; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:SFO07781.1};
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000198806};
KW Transferase {ECO:0000313|EMBL:SFO07781.1}.
FT DOMAIN 13..330
FT /note="Aminotransferase class I/classII"
FT /evidence="ECO:0000259|Pfam:PF00155"
FT DOMAIN 378..574
FT /note="Cobalamin biosynthesis precorrin-8X methylmutase
FT CobH/CbiC"
FT /evidence="ECO:0000259|Pfam:PF02570"
SQ SEQUENCE 578 AA; 65516 MW; 3E59E53A185DB35E CRC64;
MFHGGDIYRN KVKIDFSVNI NPLGMPAAVR KALLEAVENC EQYPDIKAER LTESLAERMG
VNKEHILLGN GASELFTAII HAVDPGRIVI PVPSFYGYER AVMSSRGEVL FYEMKEEMGY
TLDKGIMEYL TEETDLLFLA NPNNPVGNLI DSALLEQIAE ECKRKQILIV LDECFLEFSG
KEERYTYKNR LETYPHVIVV SAFTKIYAIP GARLGYLFCG DKELRNRIEK HLPEWNLSVF
AQAAGIAACQ EKEYIEESIQ VVETERQYLK GQLEQLGIKV YPSDADYLLI RTDLQLYDEL
LKKEILIRDC SNFRGLGRGY YRIAVKKHSD NVMLIKGVKE MLQGDIMFGR LKEIHSFQYV
ERSMDIKMHN IEFVLPEEIE KRSFEIISRE LKERNILLPP EQEMVTKRVI HTSADFEYAD
TLVFSEGAVE KGKQLIKEGA DIVTDTNMAM AGINKTVLAR FGGSAHCFMA EKEIAVLAKE
RQITRAAVSM EWASKIEKPV IFVVGNAPTA LVQLYEMIES RMFRPAFIIG VPVGFVNVEA
AKELILKTDV PYIVNRGRKG GSNVAAAICN AILYELGR
//
