ID A0A1I5EIL9_9ACTN Unreviewed; 563 AA.
AC A0A1I5EIL9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Uroporphyrinogen-III synthase /uroporphyrinogen-III C-methyltransferase {ECO:0000313|EMBL:SFO11347.1};
GN ORFNames=SAMN04489713_104140 {ECO:0000313|EMBL:SFO11347.1};
OS Actinomadura madurae.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=1993 {ECO:0000313|EMBL:SFO11347.1, ECO:0000313|Proteomes:UP000183413};
RN [1] {ECO:0000313|EMBL:SFO11347.1, ECO:0000313|Proteomes:UP000183413}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43067 {ECO:0000313|EMBL:SFO11347.1,
RC ECO:0000313|Proteomes:UP000183413};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; FOVH01000004; SFO11347.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5EIL9; -.
DR STRING; 1993.SAMN04489713_104140; -.
DR eggNOG; COG0007; Bacteria.
DR eggNOG; COG1587; Bacteria.
DR InParanoid; A0A1I5EIL9; -.
DR Proteomes; UP000183413; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SFO11347.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000183413};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SFO11347.1}.
FT DOMAIN 52..250
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 298..528
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 59242 MW; 76C809EC515D9255 CRC64;
MSPAAKSTAA EKTTTDKPTD KHTADSTATA AKGARTRAAV AASARRTADP GTVAIVGMGP
GDPGLLTLRA AAELERADTV IVSRAHCPAE ILTHCRPDAE IIDTAEGDPV KLAARAAKAG
RRVVRLFRGD PGVACSFAAE GGALAKAGVP FEVVPGVSSV TGVPGYAGIP LTDAKNREIR
IVDASEGGVD WERYAAPDTT LVILGAEGAV AEVAKGLVAA GRPDSTPAAM TSLGTTTEQE
TVVSTLQKLA SDTKGMEAPA LIIVGDVVSW RDKLSWFETK PLFGWRVLVP RTKEQAASLS
DQLRGYGAVP DEVPTISVEP PRTPQQMDRA VKGLVTGRYE WVVFTSTNAV KAIREKFTDY
GLDARAFAGL KVAAVGEQTA AALVEFGVQP DLTPSGEQSG EGLAREWPPY DEDLDPINRV
LLPRADIATD VLIARLTELG WECEDVTAYR TVRAAPPPAP IREAIKGGGF DAVLFTSSST
VKNLIGIAGK PHNVTVIAVI GPQTAKTARE YGLRVDVEAD KPSVSALAEA LAEYGAKRRA
AQIEAGDPLR KPSQMRRGAR RRR
//