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Database: UniProt
Entry: A0A1I5EIL9_9ACTN
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ID   A0A1I5EIL9_9ACTN        Unreviewed;       563 AA.
AC   A0A1I5EIL9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Uroporphyrinogen-III synthase /uroporphyrinogen-III C-methyltransferase {ECO:0000313|EMBL:SFO11347.1};
GN   ORFNames=SAMN04489713_104140 {ECO:0000313|EMBL:SFO11347.1};
OS   Actinomadura madurae.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=1993 {ECO:0000313|EMBL:SFO11347.1, ECO:0000313|Proteomes:UP000183413};
RN   [1] {ECO:0000313|EMBL:SFO11347.1, ECO:0000313|Proteomes:UP000183413}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43067 {ECO:0000313|EMBL:SFO11347.1,
RC   ECO:0000313|Proteomes:UP000183413};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005879}.
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DR   EMBL; FOVH01000004; SFO11347.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I5EIL9; -.
DR   STRING; 1993.SAMN04489713_104140; -.
DR   eggNOG; COG0007; Bacteria.
DR   eggNOG; COG1587; Bacteria.
DR   InParanoid; A0A1I5EIL9; -.
DR   Proteomes; UP000183413; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
DR   SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:SFO11347.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183413};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SFO11347.1}.
FT   DOMAIN          52..250
FT                   /note="Tetrapyrrole methylase"
FT                   /evidence="ECO:0000259|Pfam:PF00590"
FT   DOMAIN          298..528
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          542..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   563 AA;  59242 MW;  76C809EC515D9255 CRC64;
     MSPAAKSTAA EKTTTDKPTD KHTADSTATA AKGARTRAAV AASARRTADP GTVAIVGMGP
     GDPGLLTLRA AAELERADTV IVSRAHCPAE ILTHCRPDAE IIDTAEGDPV KLAARAAKAG
     RRVVRLFRGD PGVACSFAAE GGALAKAGVP FEVVPGVSSV TGVPGYAGIP LTDAKNREIR
     IVDASEGGVD WERYAAPDTT LVILGAEGAV AEVAKGLVAA GRPDSTPAAM TSLGTTTEQE
     TVVSTLQKLA SDTKGMEAPA LIIVGDVVSW RDKLSWFETK PLFGWRVLVP RTKEQAASLS
     DQLRGYGAVP DEVPTISVEP PRTPQQMDRA VKGLVTGRYE WVVFTSTNAV KAIREKFTDY
     GLDARAFAGL KVAAVGEQTA AALVEFGVQP DLTPSGEQSG EGLAREWPPY DEDLDPINRV
     LLPRADIATD VLIARLTELG WECEDVTAYR TVRAAPPPAP IREAIKGGGF DAVLFTSSST
     VKNLIGIAGK PHNVTVIAVI GPQTAKTARE YGLRVDVEAD KPSVSALAEA LAEYGAKRRA
     AQIEAGDPLR KPSQMRRGAR RRR
//
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