ID A0A1I5F0Q5_9FIRM Unreviewed; 313 AA.
AC A0A1I5F0Q5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000313|EMBL:SFO16911.1};
GN ORFNames=SAMN04489757_11195 {ECO:0000313|EMBL:SFO16911.1};
OS Anaerocolumna aminovalerica.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaerocolumna.
OX NCBI_TaxID=1527 {ECO:0000313|EMBL:SFO16911.1, ECO:0000313|Proteomes:UP000198806};
RN [1] {ECO:0000313|EMBL:SFO16911.1, ECO:0000313|Proteomes:UP000198806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1283 {ECO:0000313|EMBL:SFO16911.1,
RC ECO:0000313|Proteomes:UP000198806};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; FOWD01000011; SFO16911.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5F0Q5; -.
DR STRING; 1527.SAMN04489757_11195; -.
DR OrthoDB; 9805416at2; -.
DR Proteomes; UP000198806; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12161; GDH_like_1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000198806}.
FT DOMAIN 21..311
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 112..283
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 313 AA; 33961 MW; 95A35C622A9F5B91 CRC64;
MKLVIIEPIG VEKERLLSLA AEALGDKIEI TYYDTKVTDT ETLIERGKDA DIIAVSNLPL
NEDVINGCKN LKLLSVAFTG VDHIAMETCK KNGVMVCNCA GYSTAAVADL VFGMIITLYR
NIIPCNKVTR EEGTKDGLIG FELEGKKFGV IGTGTIGMRV ANIARAFGCE VYAYSRTQKE
VQGITYVDLD TLLSTCDIVS IHTPLNESTK GLIHGEKLAL MKKNAILINT ARGPIVDSKA
LADALNSGKI AGAGIDVFEK EPPIEKDHPL FHTPNTVVAP HIGFATKEAL VKRAVIVFDN
VVKWMENKPQ NVM
//
