ID A0A1I5G4R5_9PSEU Unreviewed; 1040 AA.
AC A0A1I5G4R5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=DNA-binding transcriptional activator of the SARP family {ECO:0000313|EMBL:SFO30987.1};
GN ORFNames=SAMN05421805_11299 {ECO:0000313|EMBL:SFO30987.1};
OS Saccharopolyspora antimicrobica.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=455193 {ECO:0000313|EMBL:SFO30987.1, ECO:0000313|Proteomes:UP000199398};
RN [1] {ECO:0000313|EMBL:SFO30987.1, ECO:0000313|Proteomes:UP000199398}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CPCC 201259 {ECO:0000313|EMBL:SFO30987.1,
RC ECO:0000313|Proteomes:UP000199398};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
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DR EMBL; FOUP01000012; SFO30987.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5G4R5; -.
DR STRING; 455193.SAMN05421805_11299; -.
DR Proteomes; UP000199398; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF13560; HTH_31; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13424; TPR_12; 3.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SMART; SM00028; TPR; 6.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50943; HTH_CROC1; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091}; TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 12..67
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT DOMAIN 74..175
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT REPEAT 907..940
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DNA_BIND 74..175
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 1040 AA; 112652 MW; 81F750CF72DFE203 CRC64;
MGTTGSTLGR LVRGFRKRAG LTQLQAAEQA GLSAAGLRDV EQGRVVRPRV STLRQLGEVL
ALSRIELESL IREAGGENSS GLRVEVLGPL RVSTGGEAVD PGSETQRVLL GLLALSPNEP
VARDALVEAV WGERSTAGSA DLLQSRVSRL RRRLQPDPAE EPVLIADRGG YQLTLSEGQH
DLLVFRRLVT GARQASKATE ACALFADAVA LWRGEPLEGL ASLQEHPLIT ALTRDYRAVL
VEYAAVAAEL GRHQEVLPHL QRVADADPLH EAVHAALMIA LAGSGQQAAA LTTFDALRRR
LADELGADPG PELTAAHQRV LRQEVLRPEF TPVSAHRQLP PDIGEFTGRE TELAALRANL
PNVGGSAVKV VLIEGMGGVG KTRLAVHAAH RLLADGRFSD CQLYVDLRGH SDQPPADPAS
VLASFLRLLG VPDDHIPSRA DERMMLFRDR LFDKKALVLL DNAADEDQVT PLLPSGAENM
VLITSRGTLA LDGAHTLPLD VFTPAEAGDM LTKAVGRDRV EVDPAAARSL VELCGRLPLA
VALAARRLQA RPKWTVRDLA GRLAECDDRL HELVAGNRRL RSVFDLSYQA LDADERRIFR
LLGLHPGDEF TADSVAALAG TTAGEARFLL DRLVDEHLAT VVTKDRYRLH DLLAEYGRGL
VREEDPAAQR SAAITRVLDF YLHSTAAATR LLQPHQPALP LVGSEPEHRP ALETPVSARQ
WLDAERACLI AAVRLAAAHG WPTHAWQLTR SLREYLHLYG YGHDHDWVRT HEAALAAAIA
AHDATGEALT RADLAATYLD LGRGAEAREH LYRALEFHRS AGDRERETST LESLGIACFR
LGEFDEALQH FRDGTALCTG HDPFRQGVLH SNLGNTLAAK GFLPEALTSL RTGLELSRQA
GNIDGQSIAL ADIGDAHRRL GDHEAALDFL DQALKLAMGH GLTPKIAYVR HRIGKVYREL
GRYPEATANL QTARRVVAKV GGPAAESEVL IDLGAAHREV GDLTTANVLL HKALSLATSR
GERHQRTLAL KELAELAEAS
//
