ID A0A1I5GDY6_9ACTN Unreviewed; 337 AA.
AC A0A1I5GDY6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=SAMN04489713_105161 {ECO:0000313|EMBL:SFO34265.1};
OS Actinomadura madurae.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=1993 {ECO:0000313|EMBL:SFO34265.1, ECO:0000313|Proteomes:UP000183413};
RN [1] {ECO:0000313|EMBL:SFO34265.1, ECO:0000313|Proteomes:UP000183413}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43067 {ECO:0000313|EMBL:SFO34265.1,
RC ECO:0000313|Proteomes:UP000183413};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
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DR EMBL; FOVH01000005; SFO34265.1; -; Genomic_DNA.
DR RefSeq; WP_075021458.1; NZ_UAPP01000002.1.
DR AlphaFoldDB; A0A1I5GDY6; -.
DR STRING; 1993.SAMN04489713_105161; -.
DR GeneID; 73569040; -.
DR eggNOG; COG3569; Bacteria.
DR InParanoid; A0A1I5GDY6; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000183413; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SFO34265.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000183413};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 19..67
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 79..286
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 337 AA; 37706 MW; A7A4C3B464B74F50 CRC64;
MRQSDPNEPG YGRRKHGRGW VYLGLDGRPL VDPAEKERIR SLVIPPAWKD VWICPDDDGH
IQAIGTDAAG RRQYLYHETW REQRDREKHE HVLELAERLP KVRDTLSNFL AGRGYSRERV
LAAAVRLIDL GFFRIGGEAY AAENQTYGLA TVLREHVTCR RGHVTFEYPA KGSKERYQAV
AEENVCKVVS GLKRRGDGGP ELLAYRTRNG WHDVTTSDIN DFVREVTEGD FTAKDFRTWH
ATVLAAVGLA VSVRAPDGDA ARRRAIVRVV KEVASYLGNT PAVARASYID PRIIELYEQD
KTIAPALDRL GVDAAEGELA TQGPVEEAVL DLLRSAP
//
