ID A0A1I5HRL1_PARPN Unreviewed; 306 AA.
AC A0A1I5HRL1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:QLH16776.1, ECO:0000313|EMBL:RKS42844.1};
GN ORFNames=BDE18_3770 {ECO:0000313|EMBL:RKS42844.1}, HYQ43_21405
GN {ECO:0000313|EMBL:QLH16776.1};
OS Paracoccus pantotrophus (Thiosphaera pantotropha).
OG Plasmid unnamed1 {ECO:0000313|EMBL:QLH16776.1,
OG ECO:0000313|Proteomes:UP000509322}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=82367 {ECO:0000313|EMBL:RKS42844.1, ECO:0000313|Proteomes:UP000273626};
RN [1] {ECO:0000313|EMBL:RKS42844.1, ECO:0000313|Proteomes:UP000273626}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35512 / DSM 2944 / CIP 106514 / LMD 82.5 / NBRC 102493 /
RC NCCB 82005 / GB17 {ECO:0000313|Proteomes:UP000273626}, and DSM 2944
RC {ECO:0000313|EMBL:RKS42844.1};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QLH16776.1, ECO:0000313|Proteomes:UP000509322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACCC10489 {ECO:0000313|EMBL:QLH16776.1,
RC ECO:0000313|Proteomes:UP000509322};
RC PLASMID=unnamed1 {ECO:0000313|EMBL:QLH16776.1,
RC ECO:0000313|Proteomes:UP000509322};
RA Si Y.;
RT "The complete genome of Paracoccus pantotrophus ACCC 10489.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP058691; QLH16776.1; -; Genomic_DNA.
DR EMBL; RBLI01000003; RKS42844.1; -; Genomic_DNA.
DR RefSeq; WP_028710259.1; NZ_RIAQ01000031.1.
DR AlphaFoldDB; A0A1I5HRL1; -.
DR GeneID; 51370941; -.
DR OrthoDB; 9793626at2; -.
DR Proteomes; UP000273626; Unassembled WGS sequence.
DR Proteomes; UP000509322; Plasmid unnamed1.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Plasmid {ECO:0000313|EMBL:QLH16776.1}.
FT DOMAIN 33..302
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 100..273
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 306 AA; 31570 MW; 4885DEA0B73B8591 CRC64;
MTRPRILALA ELKPQDMADR LAAEYRVIRD IGDAADVEAV LTAGNVGITA AQMARLPALR
LIAVNGVGVD AVDLAEARRR GIAVTTTPDV LSLAVAEMAL GLALAAGRRI AEGDRFVRAG
QWSSGGKLGL GLSVLERRAG ILGYGRIGRR LADLLRGMGM AVLYTARHER PDAPDGFRPD
ALALARDCEL LFVTAAGGKD TRGLVDAGVL AALGPDGVLV NVARGPVVDA GALAAALHAG
AIAGAGLDVF DDEPNVPQAL LDAPNCVLTP HIGSATAEAR RAMAQLVLDN IAAHFAGRPL
PTPYEA
//
