ID   A0A1I5HSR9_9BACT        Unreviewed;       619 AA.
AC   A0A1I5HSR9;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Chloride channel protein, CIC family {ECO:0000313|EMBL:SFO51179.1};
GN   ORFNames=SAMN04487852_10255 {ECO:0000313|EMBL:SFO51179.1};
OS   Prevotella sp. tf2-5.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=1761889 {ECO:0000313|EMBL:SFO51179.1, ECO:0000313|Proteomes:UP000198673};
RN   [1] {ECO:0000313|EMBL:SFO51179.1, ECO:0000313|Proteomes:UP000198673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TF2-5 {ECO:0000313|EMBL:SFO51179.1,
RC   ECO:0000313|Proteomes:UP000198673};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FOWK01000002; SFO51179.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I5HSR9; -.
DR   STRING; 1761889.SAMN04487852_10255; -.
DR   Proteomes; UP000198673; Unassembled WGS sequence.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   CDD; cd02205; CBS_pair_SF; 1.
DR   CDD; cd00400; Voltage_gated_ClC; 1.
DR   Gene3D; 3.90.1280.20; -; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR   PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
DR   PROSITE; PS51371; CBS; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198673};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        47..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        137..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        218..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        257..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        296..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        408..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          559..616
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   619 AA;  68749 MW;  8D36CCFA0CF1AC5F CRC64;
     MTEEIWFFSH LFVPLCLRMD KVSETERPTW IQRLHAWRVE HVSDRMFLLV LAFFVGLFSA
     VAAFVLHGMI NQIVALLTGQ FSVTSYNWLY LVYPVIGIYL TSLFVRHIVK DNISHGITRI
     LYAISSNKSR LKAHNTWSSV IASAITIGFG GSVGAEAPIV LTGSAIGSNL GQLFKLDSKT
     LMTLVGCGAA GAIAGIFKAP IAGLVFTLEV LMIDLTMASL LPILVSCVTA TCFTYIFSGN
     AVLFSFHLDS DWTVQRVPAT ILLGICCGLV SLYFIRTMNL CEDMFARFKD KPYIRLVIGG
     LILSTLIFLF PSLYGEGYHA INLLLNGKTE ADWNQILDNS LFYGHHELLM GYIALVLFTK
     VFATSATNGG GGCGGTFAPS LFIGCFTGFL FSRLWNMNQV GVYVPEKNFA LLGMAGVMSG
     VMHAPLTGIF LIAEITSGYN LFVPLMIVSV FAYLTIIIFE PHSIYGMRLA RQGKLITHHT
     DHAVLTLMSL DSVIDRDYQG VDADMELGQM VHKISRSRHS VLPVVDAAGS LLGEINIVKI
     RHVVFRTELY HHFKASQLMT APAAVLDDGT SMTEVMRTFE RTQADWLPVL DEERHLKGYI
     SRKRMYSVYR KMVHDFSQE
//