ID A0A1I5IGK9_9ACTN Unreviewed; 495 AA.
AC A0A1I5IGK9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase {ECO:0000313|EMBL:SFO59386.1};
GN ORFNames=SAMN04489713_107314 {ECO:0000313|EMBL:SFO59386.1};
OS Actinomadura madurae.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=1993 {ECO:0000313|EMBL:SFO59386.1, ECO:0000313|Proteomes:UP000183413};
RN [1] {ECO:0000313|EMBL:SFO59386.1, ECO:0000313|Proteomes:UP000183413}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43067 {ECO:0000313|EMBL:SFO59386.1,
RC ECO:0000313|Proteomes:UP000183413};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FOVH01000007; SFO59386.1; -; Genomic_DNA.
DR RefSeq; WP_075022026.1; NZ_UAPP01000005.1.
DR AlphaFoldDB; A0A1I5IGK9; -.
DR STRING; 1993.SAMN04489713_107314; -.
DR GeneID; 73570866; -.
DR eggNOG; COG1010; Bacteria.
DR eggNOG; COG2243; Bacteria.
DR InParanoid; A0A1I5IGK9; -.
DR OrthoDB; 9804789at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000183413; Unassembled WGS sequence.
DR GO; GO:0030788; F:precorrin-2 C20-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11645; Precorrin_2_C20_MT; 1.
DR CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR InterPro; IPR012382; CobI/CbiL.
DR InterPro; IPR006364; CobI/CbiL/CobIJ_dom.
DR NCBIfam; TIGR01467; cobI_cbiL; 1.
DR NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF00590; TP_methylase; 2.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 2.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SFO59386.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000183413};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SFO59386.1}.
FT DOMAIN 4..217
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 256..462
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 495 AA; 52535 MW; C8F0D2ECD9690436 CRC64;
MAGRLFGVGV GPGDPELVTV KAARLIGDAD VVAFHCARHG RSIARSVAEP YLRDGQVEEQ
LVYPVTTETT DHPGGYEGAL DEFYADCAAR LAAHLDAGRT VVVLSEGDPL FYGSYMHLHK
RLASRYPTEV VPGVTSLSAA SAAAGRPLAE REETLTVLPG TLPGEELAER LRDTDAAAVL
KLGRTFPKVR QAFEDAGRLG DAWYVERASS ERERVVPLAD VDPADVPYMS LALLTSPAEK
SFTAPPPGPA HGSGAVTVVG LGPAGRPWLT PEAQDVLASA TDLVGYGPYL DRVPANPRQR
RHSSGNRVEA DRARQALTLA RDGARVAVVS SGDPGVFAMA AAVLEVAAED EFADVPVRVV
PGLTAAQAVA ARAGAPLGHD FCVLSLSDIL KPWDVIARRL RAAAEADLVL ALYNPASSRR
RHQLPAARDL LLEHRSPETP VVVGRDVGGP EESVTVTTLG KLDPEDVDMR CLLIIGSSTT
RVTDQGVVYT PRRHP
//
