ID A0A1I5KD20_9RHOB Unreviewed; 706 AA.
AC A0A1I5KD20;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=GTP pyrophosphokinase rsh {ECO:0000256|ARBA:ARBA00014315};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
GN ORFNames=SAMN04488047_10131 {ECO:0000313|EMBL:SFO82907.1};
OS Tranquillimonas alkanivorans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Tranquillimonas.
OX NCBI_TaxID=441119 {ECO:0000313|EMBL:SFO82907.1, ECO:0000313|Proteomes:UP000199356};
RN [1] {ECO:0000313|EMBL:SFO82907.1, ECO:0000313|Proteomes:UP000199356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19547 {ECO:0000313|EMBL:SFO82907.1,
RC ECO:0000313|Proteomes:UP000199356};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; FOXA01000001; SFO82907.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5KD20; -.
DR STRING; 441119.SAMN04488047_10131; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000199356; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 2.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:SFO82907.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199356};
KW Transferase {ECO:0000313|EMBL:SFO82907.1}.
FT DOMAIN 45..144
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 382..447
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 706 AA; 80264 MW; 2713831D653DC855 CRC64;
MIDVDDLIAL VRNYNPKTNE GLIREAFDYG QRMHEGQFRH SGEPYFTHPV AVAAILTEMQ
LDDSTIVTAL LHDVIEDTRS TYGEVVDRFG FEIAELVDGV TKLTNLQLTS TETKQAENFR
KLFMAMSKDL RVILVKLADR LHNMRTIKSM RHEKQVQKAR ETMDIFAPLA GRMGMQWMRE
ELEDLAFQVL NPDGRRSIIR RFVTLQRETG DVIDKITTDI RHELDKVGIE AEVFGRAKKP
FSIWRKMQEK EMGFSRLSDI YGFRVICNSE MDCYGVLGAI HQRWRAVPTR FKDYISQPKS
NGYRSIHTTV SGRDGKRVEV QIRTREMHEV AETGVAAHWS YRDGVRAENR FAVDPARWIS
SLTERFHAAE DHDEFLEAVK LEMYQDQVFC FTPKGDVVKL PKGATPLDFA YAIHTRIGDS
CVGAKVDAIR VPLWTRLKNG QSVEILTAEG QRPQATWIDI VATGRAKTAI RRSLREEDRE
RFIKLGRELA RVAFDHVGKR VTDKALATAA RQMGLAGSDE VLARLGSAEL TARKVVETLY
PELARHRGEE VEAQRAVVGL SPEQKYARAQ CCQPLPGERI VGIGYSGRGV VIHAIDCPAL
EEFESQNDRW VDLHWHSGVH RAVNTVSFDM TISNDAGVLG RICTLIGEQK ANISDLRFVD
RKPDFYRLIV DVDLRDVEHM HAVMLGLEAD SDVASIVRHR DLGRRP
//
