ID A0A1I5L5S7_9ACTN Unreviewed; 1130 AA.
AC A0A1I5L5S7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN05660464_1565 {ECO:0000313|EMBL:SFO92558.1};
OS Geodermatophilus dictyosporus.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Geodermatophilus.
OX NCBI_TaxID=1523247 {ECO:0000313|EMBL:SFO92558.1, ECO:0000313|Proteomes:UP000198857};
RN [1] {ECO:0000313|Proteomes:UP000198857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44208 {ECO:0000313|Proteomes:UP000198857};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; FOWQ01000002; SFO92558.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5L5S7; -.
DR STRING; 1523247.SAMN05660464_1565; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000198857; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000198857}.
FT DOMAIN 48..383
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 384..695
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1130
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 69..76
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1130 AA; 119834 MW; 690C08A675A25D99 CRC64;
MSRRTPAPPE EQLSFDDDAL FGSAPVPERP RRLLTPAEVA ERCGLTYAPS GEQAGVVSAP
ADRPLVVVAG AGSGKTETMA ARVCWLVANE LVAPDAILGL TFTRKAASEL NERIRIRLAA
LARHPETDAQ LRERLAVAVP TVSTYHGYAA SLVSEHGLRI GVEPGAGVLG PAMCWGQAAA
VVSGWTGDMD DVPLTPLTTV EDVLALAGEL GEHDIAPERL REWTAQLQAR IAGYPDAPRK
RGPYAPVLEM LARQRARVAL LPLVAAFEAR KRAAGAIDHS DQVALAARVA VTAPEVGRRE
RARWQVVLLD EYQDTSVGQL RMLEALFGRT SGHAVLAVGD PRQSIYGWRG ASAGTIERFA
RTFPGVRGRE SRRLTLATSW RNDAAVLQVA NAVAGLLPAP DVPLPDLTPA PTAGGGLVTA
GLYTTVAEET EALADRLAAC WRGEDPALPP RPDGRPPTTA VLVRTRRQLP GIAAALRARG
LPVTVVGLGG LLEVPEVSDV VATLTVLVDP SAGDAMGRLL TGARWRIGPR DLAALESRAR
TLVRSRRPAR EDDDDPAARP SERGSLVEAL DDLGDPSAYS AVAYRRLRRL AGELAQLRGR
LGDALPDLVD EVARTLGLET ELASAPGVSP GAARAHLDAL HAVAAEFTEL AELPSLPAFL
GYLRDAEERE RGLEPGEVAV DPESIQLLTG HSAKGLEWDV VAVPGMTADQ FPARTDTADS
WVRDPGAVPV DLRTTDRDEL PQLRLPVPGS GDQAAVRAAL EDYVEEWKGF GESEEIRLGY
VAVTRAKHLL VCSGSWWREG VRPNGPSVLL DTVRRACGAG AGVVVAWAER PEEGATNPAL
EEWPVGVWPA DPLSAPRRRA LTAAAELVAG SAAHPLDPDA ALGTADPVVE QWVRDADLLL
RERRRAARPS VEVPLPSHLS VSELVALRRD PAGLARRLRR PMPSAPAPLA RRGTAFHAWI
EERFGAARLL DLDELPGSGD AGAAPDGALA ALQEAFLASG WADRQPVEVE VPFETPLGPL
TLRGRIDAVF GDGEGGFEVV DWKTGPPPSG AELASAAVQL AAYRLGWSRL AGVPVERVSA
GFHHVAAGVT VRPVDLLDEA GLLALVTGED LPAEPPDDDL PPPPEDDGLG
//