ID A0A1I5LR45_9BACT Unreviewed; 1094 AA.
AC A0A1I5LR45;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN04487852_11262 {ECO:0000313|EMBL:SFO99720.1};
OS Prevotella sp. tf2-5.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=1761889 {ECO:0000313|EMBL:SFO99720.1, ECO:0000313|Proteomes:UP000198673};
RN [1] {ECO:0000313|EMBL:SFO99720.1, ECO:0000313|Proteomes:UP000198673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TF2-5 {ECO:0000313|EMBL:SFO99720.1,
RC ECO:0000313|Proteomes:UP000198673};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; FOWK01000012; SFO99720.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5LR45; -.
DR STRING; 1761889.SAMN04487852_11262; -.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000198673; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SFO99720.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198673};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SFO99720.1}.
FT DOMAIN 494..629
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 742..843
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 1094 AA; 127913 MW; 54B033021A63DCB5 CRC64;
MNKRTFSNFL SESNFRELFI SEMGWNNPSG ATLLPEYTID EKVYSIEQIA DCRGFQILQC
QTDEIPSSSI CKKLDTKLRK NAEHYICIFS VPNTLHHLWV TPVKKVEKRD LVLVEYDTID
KASFLFEKME GLSFSFDAQP TIIDVIDRVQ NAFIVNSEKV TKDFYAGFKK EHTNFVKFIS
GIDDEIADDD NKKKQWYTSV MLNRLMFCYF IQKKGFLNGD VDYLRHKLEW TQQEQGENRF
FSTFYKGFLV NLFHDGLNAP EHDAKFEETY GRIPYLNGGM FDIHQLENEY KGHDIADEAF
ISLFDFFDKW HWHLDDRMTA TGKDINPDVL GYIFEQYIND RAEMGAYYTK EDITEYIGRN
TIIPYLLNSV KQKDSSYFTP TNEFWQYLKN SDDKYIFDSV KKGANLPIPN DVADGFDTTT
PQLIERRKCW NDKTPEAYAL PTEIWRETIG RIEYYKSTRS KINNGELTEI DDFVTYNLDI
RQFLLDYLTK TQDSRFIELL YDELQSITIL DPTCGSGAFL FAALNILEPL YEICISRMQE
FNEKDNCLFV RQLKEIENKY RSNIQYFIYK SIILRNLYGV DIMVEAIEIA KLRLFLKMVA
VVEVDKRDKN LGLDPLPDID FNIRCGNTLV GYATENELEK DLFEGDMFAI AEFKEKVRKE
MGFVAQVFDK FKETQLRQTE DLATFKLAKK ELKESLTSLN DLLNHQMCSS LANGTNYDEW
LRTHQPFHWL AEFYEIINDG GFDIIIGNPP YVVYTESKSQ YRVSADYKTK DCANLYAYCV
ERSQNILNIN GRFGMIVPNS SISANKMLPL QKIITQNSNT WISNYSWRPS KLFEGADMLL
AIILRCHSNK SKIYSTIYHK WYNEYRSSLF KCIKYTEATT TKIDGSIPKL PSDFVVSILK
DMKAKAGNHI LPESFVETSN HKLFYFRAVQ YWFKILDREP IFEEDGVHKT TGEMKPLGFD
SLAKRNAAIA ILSSNLFFLN YIIWSSCQVV NSRDFNIPFD FSSLTADERE SLANLGARLQ
EDYQKHSHVK ERNYSKKGRV FTMQKQHFFI KYSKSIIDEI DKVLSGYYGF TDEELDFIIN
YDIKYRMGDE LSEE
//
