ID A0A1I5QP06_9FIRM Unreviewed; 867 AA.
AC A0A1I5QP06;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN05216343_10827 {ECO:0000313|EMBL:SFP48038.1};
OS Oscillibacter sp. PC13.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Oscillibacter.
OX NCBI_TaxID=1855299 {ECO:0000313|EMBL:SFP48038.1, ECO:0000313|Proteomes:UP000198573};
RN [1] {ECO:0000313|EMBL:SFP48038.1, ECO:0000313|Proteomes:UP000198573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC13 {ECO:0000313|EMBL:SFP48038.1,
RC ECO:0000313|Proteomes:UP000198573};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FOXE01000008; SFP48038.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5QP06; -.
DR STRING; 1855299.SAMN05216343_10827; -.
DR Proteomes; UP000198573; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000198573}.
FT DOMAIN 700..716
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 509..536
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 626..633
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 867 AA; 95736 MW; 49B4D4EFA340D51C CRC64;
MAELTPMMKQ YLEIKKDNPD SILFFRLGDF YEMFADDART ASQELDLTLT SRDKDPNKSA
EEKIPMCGIP YHASESYIAR LIAKGYKVAI CEQLEDPALA KGLVKRDIIR VVTPGTVIDA
ACLDDKAANF LCGIYLDERS AGVAFCDIST GKTHLTAFTG KERVEHVINE LGRFSPAEAI
LSDGAYAEGP LTDALREKFS CRVENGGARR FLLPEAERNI RAQYGDEAFS RLPAGNPAAA
MALGGLLSYL YETQKTDLSH IRDLDYYEQG RFMELDLTAR RNLELTETLR GKEKKGSLLW
VLDKTKTPMG ARCLRSFLER PLLSVTAITK RNAAVGALVE STMAREELIA AMTGLGDMER
LIGRIVYGTA GGKDMNSLRA AIERLPAIET QLGAFTDRRL SELRRELDTL DDVGGTIASA
IDDDPPFSIR EGGFIRPGFD GEVDRLRGIL KGGKGVIAEM EAREKERTGI RTLKIGYNKV
FGYYIEVSNS FKELVPPEYI RKQTLVNGER FITEELKNLE HEILTASERV VALEYELFGK
LREEVSAAAA RIQKTAAAVA EVDALASFAA VAVRNRYCRP DVDESGVIEI REGRHPVVEQ
VLKNNLFVPN DTFMGEKEER VAIITGPNMA GKSTYMRQVA LIVLMAQMGS FVPASHARIG
VVDRIFTRIG ASDDLSAGQS TFMVEMTEVA EILHHATRNS LLILDEIGRG TSTFDGMSIA
RAVLEYCADK KLLGAKTLFA THYHELTELE NTLPGTVNYN IAVKTRGEDI IFLRKIVAGG
ADRSYGIEVA KLAGLPDKVV QRAKTVLTEL ESENGVQYVA ARKETEQVSL GSISEGEVLD
ALRRCQPDTL TPIEAMSLLY ELKQKLS
//
