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Database: UniProt
Entry: A0A1I5R7C7_9FIRM
LinkDB: A0A1I5R7C7_9FIRM
Original site: A0A1I5R7C7_9FIRM 
ID   A0A1I5R7C7_9FIRM        Unreviewed;       320 AA.
AC   A0A1I5R7C7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU362028};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362028};
GN   ORFNames=SAMN05216343_10936 {ECO:0000313|EMBL:SFP54429.1};
OS   Oscillibacter sp. PC13.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Oscillibacter.
OX   NCBI_TaxID=1855299 {ECO:0000313|EMBL:SFP54429.1, ECO:0000313|Proteomes:UP000198573};
RN   [1] {ECO:0000313|EMBL:SFP54429.1, ECO:0000313|Proteomes:UP000198573}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC13 {ECO:0000313|EMBL:SFP54429.1,
RC   ECO:0000313|Proteomes:UP000198573};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil.
CC       {ECO:0000256|RuleBase:RU362028}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC         Evidence={ECO:0000256|RuleBase:RU362028};
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000256|ARBA:ARBA00010876, ECO:0000256|RuleBase:RU362028}.
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DR   EMBL; FOXE01000009; SFP54429.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I5R7C7; -.
DR   STRING; 1855299.SAMN05216343_10936; -.
DR   OrthoDB; 9807829at2; -.
DR   Proteomes; UP000198573; Unassembled WGS sequence.
DR   GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   NCBIfam; TIGR00005; rluA_subfam; 1.
DR   PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR   PANTHER; PTHR21600:SF83; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE RPUSD4; 1.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|RuleBase:RU362028};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198573};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT   DOMAIN          93..253
FT                   /note="Pseudouridine synthase RsuA/RluA-like"
FT                   /evidence="ECO:0000259|Pfam:PF00849"
FT   ACT_SITE        147
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606225-1"
SQ   SEQUENCE   320 AA;  36767 MW;  127B3CD8C6CB48B7 CRC64;
     MREFTIGKND AGQRLDRFVA KNLPLLPPAL LQKYIRLKRI KVNGRGSKRD VRLESGDILQ
     LYINDEFFDK PSEENLFLTL FQPKLTIVYE DENLLLVDKR PGIVVHADET EKVNTLINHI
     QAYLYQKREW NPKWEHAFAP ALCNRIDRNT GGIVIAAKNA ETLRIMNEKI KSHEVEKSYL
     CITVGHPRPA EGKIEGFLLK DEAKKEVSFY HRPIPGGKTA VTLYKTMESR GPLSLVECRL
     LTGRTHQIRV SMAEIGCPLL GDGKYGNGAV NRQYHETRQA LYSYKLSFSF PTDAGVLNYL
     RGREFTVEEV PFQEKYFPRL
//
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