ID A0A1I5R7C7_9FIRM Unreviewed; 320 AA.
AC A0A1I5R7C7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU362028};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362028};
GN ORFNames=SAMN05216343_10936 {ECO:0000313|EMBL:SFP54429.1};
OS Oscillibacter sp. PC13.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Oscillibacter.
OX NCBI_TaxID=1855299 {ECO:0000313|EMBL:SFP54429.1, ECO:0000313|Proteomes:UP000198573};
RN [1] {ECO:0000313|EMBL:SFP54429.1, ECO:0000313|Proteomes:UP000198573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC13 {ECO:0000313|EMBL:SFP54429.1,
RC ECO:0000313|Proteomes:UP000198573};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil.
CC {ECO:0000256|RuleBase:RU362028}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in RNA = a pseudouridine in RNA;
CC Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|RuleBase:RU362028};
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000256|ARBA:ARBA00010876, ECO:0000256|RuleBase:RU362028}.
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DR EMBL; FOXE01000009; SFP54429.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5R7C7; -.
DR STRING; 1855299.SAMN05216343_10936; -.
DR OrthoDB; 9807829at2; -.
DR Proteomes; UP000198573; Unassembled WGS sequence.
DR GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR NCBIfam; TIGR00005; rluA_subfam; 1.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF83; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE RPUSD4; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362028};
KW Reference proteome {ECO:0000313|Proteomes:UP000198573};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT DOMAIN 93..253
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
FT ACT_SITE 147
FT /evidence="ECO:0000256|PIRSR:PIRSR606225-1"
SQ SEQUENCE 320 AA; 36767 MW; 127B3CD8C6CB48B7 CRC64;
MREFTIGKND AGQRLDRFVA KNLPLLPPAL LQKYIRLKRI KVNGRGSKRD VRLESGDILQ
LYINDEFFDK PSEENLFLTL FQPKLTIVYE DENLLLVDKR PGIVVHADET EKVNTLINHI
QAYLYQKREW NPKWEHAFAP ALCNRIDRNT GGIVIAAKNA ETLRIMNEKI KSHEVEKSYL
CITVGHPRPA EGKIEGFLLK DEAKKEVSFY HRPIPGGKTA VTLYKTMESR GPLSLVECRL
LTGRTHQIRV SMAEIGCPLL GDGKYGNGAV NRQYHETRQA LYSYKLSFSF PTDAGVLNYL
RGREFTVEEV PFQEKYFPRL
//