ID A0A1I5RDA5_9SPHN Unreviewed; 321 AA.
AC A0A1I5RDA5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=uroporphyrinogen decarboxylase {ECO:0000256|ARBA:ARBA00012288};
DE EC=4.1.1.37 {ECO:0000256|ARBA:ARBA00012288};
GN ORFNames=SAMN04488241_103181 {ECO:0000313|EMBL:SFP56499.1};
OS Sphingomonas rubra.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=634430 {ECO:0000313|EMBL:SFP56499.1, ECO:0000313|Proteomes:UP000199586};
RN [1] {ECO:0000313|EMBL:SFP56499.1, ECO:0000313|Proteomes:UP000199586}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.9113 {ECO:0000313|EMBL:SFP56499.1,
RC ECO:0000313|Proteomes:UP000199586};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00004804}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC {ECO:0000256|ARBA:ARBA00009935}.
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DR EMBL; FOXP01000003; SFP56499.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5RDA5; -.
DR STRING; 634430.SAMN04488241_103181; -.
DR UniPathway; UPA00251; UER00321.
DR Proteomes; UP000199586; Unassembled WGS sequence.
DR GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00717; URO-D; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR NCBIfam; TIGR01464; hemE; 1.
DR PANTHER; PTHR21091; METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED; 1.
DR PANTHER; PTHR21091:SF169; UROPORPHYRINOGEN DECARBOXYLASE; 1.
DR Pfam; PF01208; URO-D; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
DR PROSITE; PS00907; UROD_2; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000199586}.
FT DOMAIN 117..133
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|PROSITE:PS00907"
SQ SEQUENCE 321 AA; 34421 MW; 98E7A3FBD717125F CRC64;
MWLMRQAGRY LPEYRALRAE KGGFLALATD PPAAAEVTMQ PIRRFGFDGA ILFSDILMVP
WALGQDLSFG AGEGPRLQPP LVDHALGELE AAHERLEPVY ATVRTVAGQL PSATTFLGFA
GSPWTVATYM VAGQGSKDHA ETRAFAYRDP AAFDRIVAAI VDLTVTYLSG QIDSGVEAVQ
LFDSWAGSLS PAQFERWVIA PNAEIVRRLR VRYPSVPIIG FPKGAGAKLV DYAAGVKPDA
IGLDETLDPA WADAALPIGM PVQGNLDPLA LLTGGAALDA GIDRVLAAFR ERPHVFNLGH
GIGQHTPIAH VEQLIRRVRG A
//
