ID   A0A1I5THW7_9BACT        Unreviewed;       417 AA.
AC   A0A1I5THW7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN   ORFNames=SAMN04515674_10651 {ECO:0000313|EMBL:SFP82451.1};
OS   Pseudarcicella hirudinis.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC   Pseudarcicella.
OX   NCBI_TaxID=1079859 {ECO:0000313|EMBL:SFP82451.1, ECO:0000313|Proteomes:UP000199306};
RN   [1] {ECO:0000313|EMBL:SFP82451.1, ECO:0000313|Proteomes:UP000199306}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E92,LMG 26720,CCM 7988 {ECO:0000313|Proteomes:UP000199306};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC       sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
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DR   EMBL; FOXH01000006; SFP82451.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I5THW7; -.
DR   STRING; 1079859.SAMN04515674_10651; -.
DR   OrthoDB; 9808591at2; -.
DR   Proteomes; UP000199306; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000385; MoaA_NifB_PqqE_Fe-S-bd_CS.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR   PANTHER; PTHR43273; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR   PANTHER; PTHR43273:SF8; RADICAL SAM PROTEIN-RELATED; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDG01072; dehydrogenase_like; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS01305; MOAA_NIFB_PQQE; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199306};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          4..235
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   417 AA;  46652 MW;  2766F74B1D250497 CRC64;
     MKERLKCQAA ILKVASRCNL NCDYCYMYNL ADKSYLGQPK FMSGKIVEAL INEVKNHCLL
     HGIKHFEFIF HGGEPLLLSP DFYIDFVETA GKVLDSVVTP GFSLQTNGVL LTDKWCEVFA
     SLGIRVGISL DGLPAIHDAH RVDHQGRGSY QATVKGLKIA QESAYLKGVP GVLTVIDVDS
     DPVETYHHLK SLGIRHVNFL FPDGNFDYLP KGIDFSGEKT LYADWLISLF DTWLNDASPK
     PEIRLFRQVM QLVLGIDNGF EYWGKRRNEF IVIETDGSIE AIGALKSCGE NFTKAGVNIL
     SASLDEALQT DLAQIYHLSH EKLCSQCLNC PVGEVCGGGY LPHRFGRNRG FNNPSVYCQD
     LLKLICHIQH SVLDDLPEEL LESIQLEKID YLELRNDLHL SGITDENPVL ESFGIKK
//