ID A0A1I5UQZ2_9SPHN Unreviewed; 522 AA.
AC A0A1I5UQZ2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
DE Flags: Fragment;
GN ORFNames=SAMN04488241_1151 {ECO:0000313|EMBL:SFP97659.1};
OS Sphingomonas rubra.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=634430 {ECO:0000313|EMBL:SFP97659.1, ECO:0000313|Proteomes:UP000199586};
RN [1] {ECO:0000313|EMBL:SFP97659.1, ECO:0000313|Proteomes:UP000199586}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.9113 {ECO:0000313|EMBL:SFP97659.1,
RC ECO:0000313|Proteomes:UP000199586};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FOXP01000015; SFP97659.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5UQZ2; -.
DR STRING; 634430.SAMN04488241_1151; -.
DR OrthoDB; 9806213at2; -.
DR Proteomes; UP000199586; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SFP97659.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199586};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SFP97659.1}.
FT DOMAIN 42..226
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:SFP97659.1"
SQ SEQUENCE 522 AA; 56791 MW; 06A99A939331D7D0 CRC64;
KPYGRLDRAV AELAQVVGRE AAPLPITEAV YFLTGLYTTL LAARERGALG AFYTPPALAN
RLLDMAEEQG IDWTRARVLD PASGGGAFLL PAAERMIAAL PEAEPAFVLR QIGTRLVGLE
LDPYAAGFGQ NAIELLLADV TSAAGRPAPT VVRVADTLEE APSARFDLVI GNPPYGRVTL
TPAQRQRFAR GLYGHANLYG VFTDIAVRWT KKGGTIAYLT PTSFLSGHYY SALRELMAKE
APPAAIDFVH TRRGVFEDVL QETLLAAYRR GAKPGRAQVH YVEVTSEREA RLIRNGTIGL
PSPASQPWLA PREPRHSALI AKAEAMPARL ADWGYSVSTG PLVWNRYKDQ MRQRSARGVH
PLIWAEAVSA DGRFAFRAEK RNHAPYFKIE RGDAWLLVEE ACVLVQRTTS KEQARRLIAA
ELPADFIAQH GGVVVENHLN MVRPVARPAV SPATVAAVLN SRIVDQLFRC INGSVAVSAF
EMEALPLPSP AAMRQVEALV GRGACSAEIE DELARLYGQV AP
//
