ID   A0A1I5VJP4_9FIRM        Unreviewed;       355 AA.
AC   A0A1I5VJP4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   ORFNames=SAMN02910358_00634 {ECO:0000313|EMBL:SFQ07527.1};
OS   Lachnospiraceae bacterium XBB1006.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1520827 {ECO:0000313|EMBL:SFQ07527.1, ECO:0000313|Proteomes:UP000199554};
RN   [1] {ECO:0000313|EMBL:SFQ07527.1, ECO:0000313|Proteomes:UP000199554}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=XBB1006 {ECO:0000313|EMBL:SFQ07527.1,
RC   ECO:0000313|Proteomes:UP000199554};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; FOXT01000005; SFQ07527.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I5VJP4; -.
DR   STRING; 1520827.SAMN02910358_00634; -.
DR   Proteomes; UP000199554; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   NCBIfam; TIGR00331; hrcA; 1.
DR   PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199554};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00081}.
FT   DOMAIN          109..332
FT                   /note="Heat-inducible transcription repressor HrcA C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01628"
SQ   SEQUENCE   355 AA;  39775 MW;  5C0561D6C905B7A3 CRC64;
     MENNVEMAPL DERKRKILSL IIRSYLETGE PVGSRTISKM LDITLSSATI RNEMSDLEDM
     GYILQPHTSA GRIPSDLGYR FYVNELMVEH DRDVAKMQEF VIEKTEKMEK MLKNVVKALA
     ANTNYATLIT SPNTSRNKVK FIQLSQVEER QLVAVIVMEG NIVKNKIMEF PEDIDAETIL
     KLNILLNSTL NGLTREEINL GVIAKMKEQS GAYSQIVNEV LDAVAEAFSE DEELQVYTSG
     ATNLIKYPEL ADTEKAGALL SAFEDKEELI EFLAETKDDN KEDGIQVYIG NESPIQTMQD
     CSVVTATYDL GNGLSGHIGI VGPKRMDYEN VMENLKSIKT QLDVAFKNND SEKPN
//