ID A0A1I5WDV2_9FIRM Unreviewed; 685 AA.
AC A0A1I5WDV2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=ATP-dependent DNA helicase RecG {ECO:0000256|ARBA:ARBA00017846, ECO:0000256|RuleBase:RU363016};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU363016};
GN Name=recG {ECO:0000256|RuleBase:RU363016};
GN ORFNames=SAMN05444406_11611 {ECO:0000313|EMBL:SFQ17855.1};
OS Caldicoprobacter faecalis.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Caldicoprobacteraceae;
OC Caldicoprobacter.
OX NCBI_TaxID=937334 {ECO:0000313|EMBL:SFQ17855.1, ECO:0000313|Proteomes:UP000198577};
RN [1] {ECO:0000313|EMBL:SFQ17855.1, ECO:0000313|Proteomes:UP000198577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20678 {ECO:0000313|EMBL:SFQ17855.1,
RC ECO:0000313|Proteomes:UP000198577};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Critical role in recombination and DNA repair. Helps process
CC Holliday junction intermediates to mature products by catalyzing branch
CC migration. Has a DNA unwinding activity characteristic of a DNA
CC helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-
CC DNA). {ECO:0000256|ARBA:ARBA00024832, ECO:0000256|RuleBase:RU363016}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363016};
CC -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC {ECO:0000256|ARBA:ARBA00007504, ECO:0000256|RuleBase:RU363016}.
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DR EMBL; FOXR01000016; SFQ17855.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I5WDV2; -.
DR STRING; 937334.SAMN05444406_11611; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000198577; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR CDD; cd17992; DEXHc_RecG; 1.
DR CDD; cd04488; RecG_wedge_OBF; 1.
DR CDD; cd18811; SF2_C_RecG; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR004609; ATP-dep_DNA_helicase_RecG.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR045562; RecG_dom3_C.
DR InterPro; IPR033454; RecG_wedge.
DR NCBIfam; TIGR00643; recG; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF19833; RecG_dom3_C; 1.
DR Pfam; PF17191; RecG_wedge; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 2.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363016};
KW DNA damage {ECO:0000256|RuleBase:RU363016};
KW DNA recombination {ECO:0000256|RuleBase:RU363016};
KW DNA repair {ECO:0000256|RuleBase:RU363016};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU363016};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363016};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363016};
KW Reference proteome {ECO:0000313|Proteomes:UP000198577}.
FT DOMAIN 275..436
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 455..615
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 685 AA; 77808 MW; 42977527092BB1C0 CRC64;
MSILKQDVQF IKGVGPKKAA RLNKLGIKTV EDALQHFPRD YEIWRGIKKV ANAVDGEDAS
FVVTFVGNAN TQKPRKGLTI TTWRAKDDTG YLWCVWFNQP YRSNMYSTDK LYFVRGRVEY
RYGMVQLQNP IVEEYVPEKH DGSKILPIYP LTEGITQKDM RNLMAEALKR VEGSLNDEFP
ADLRKRFKLA EKNFAMRHIH FPQSLQALEE ARRRLVFEEL FFMKMALHLI REKNHSNNRG
LSFEWDHKAF EEFVQRLPFP LTNAQKRVVD EILRDLKSGR VMNRLVQGDV GSGKTVVAAL
ALYCAVLSGY QGAMMVPTEI LARQHYATLK ELFDGTGVKV ECLVGGMKNV EKESIRFRLA
TGDIDILVGT HAVIEDGVNF KNLGLVITDE QHRFGVRQRA ALQQKGQSPH MLVMSATPIP
RTLALMFYGD LDVSVIDELP PGRKPVKTYH VPPSMKDRVL EFIKRQVAEG RQAYMVCPLV
EESDAIDSQS AIELFETLRR GELADLRLGL LHGRMKPAEK ESVMEAFAAG QIDVLISTTV
IEVGVNVPNA TVMVIENAER FGLAQLHQLR GRVGRGEHQS YCILIADAKT KEIYERMKVM
TKSNDGFEIA EKDLQLRGPG DFLGVKQHGL PEFKIANLVR DIGILKQVDL AVRQVLQQRD
NPAYKALIEY TMDKFNEQLN EITFN
//
